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首页> 外文期刊>Journal of Anatomy >Testosterone-immunopositive primordial germ cells in the testis of the bullfrog, Rana catesbeiana.
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Testosterone-immunopositive primordial germ cells in the testis of the bullfrog, Rana catesbeiana.

机译：牛蛙Rana catesbeiana睾丸中的睾丸激素免疫阳性原始生殖细胞。

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摘要

Abstract In amphibia, steroidogenesis remains quiescent in distinct seasonal periods, but the mechanism by which spermatogenesis is maintained under low steroidogenic conditions is not clear. In the present study, testosterone location in the testes of Rana catesbeiana was investigated immunohistochemically during breeding (summer) and nonbreeding (winter) periods. In winter, the scarce interstitial tissue exhibited occasional testosterone immunopositivity in the interstitial cells but the cytoplasm of primordial germ cells (PG cells) was clearly immunopositive. By contrast, in summer, PG cells contained little or no immunoreactivity whereas strong immunolabelling was present in the well-developed interstitial tissue. These results suggest that PG cells could retain testosterone during winter. This androgen reservoir could be involved in the control of early spermatogenesis in winter and/or to guarantee spermiogenesis and spermiation in the next spring/summer. The weak or negative immunoreaction in thesummer PG cells might reflect consumption of androgen reservoir by the intense spermatogenic activity from spring to summer. Thus, besides acting as stem cells, PG cells of R. catesbeiana could exert an androgen regulatory role during seasonal spermatogenesis.
机译：摘要在两栖动物中，类固醇生成在不同的季节期间保持静止，但在低类固醇生成条件下维持精子生成的机制尚不清楚。在本研究中，在繁殖期（夏季）和非繁殖期（冬季）进行了免疫组织化学的Rana catesbeiana睾丸睾丸激素定位研究。在冬季，稀疏的间质组织偶尔在间质细胞中表现出睾丸激素免疫阳性，但原始生殖细胞（PG细胞）的细胞质显然具有免疫阳性。相比之下，在夏天，PG细胞几乎没有免疫反应，而发达的间质组织中则存在强免疫标记。这些结果表明，PG细胞可以在冬季保留睾丸激素。该雄激素储库可参与冬季冬季早期精子发生的控制和/或在下一个春季/夏季保证精子发生和精子化。夏季PG细胞中弱或阴性的免疫反应可能反映了春季至夏季强烈的生精活性，从而消耗了雄激素。因此，除了常规的干细胞外，R。catesbeiana的PG细胞还可以在季节性精子发生过程中发挥雄激素的调节作用。

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