Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media

Vandsburger Moriel; Vandoorne Katrien; Oren Roni; Leftin Avigdor; Mpofu Senzeni; Castelli Daniela Delli; Aime Silvio; Neeman Michal

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Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media

机译：心脏化学交换饱和转移磁共振成像揭示了内源性纤维化和外源性造影剂的分子特征

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Background-Application of emerging molecular MRI techniques, including chemical exchange saturation transfer (CEST)-MRI, to cardiac imaging is desirable; however, conventional methods are poorly suited for cardiac imaging, particularly in small animals with rapid heart rates. We developed a CEST-encoded steady state and retrospectively gated cardiac cine imaging sequence in which the presence of fibrosis or paraCEST contrast agents was directly encoded into the steady-state myocardial signal intensity (cardioCEST).

机译：背景技术新兴的分子MRI技术（包括化学交换饱和转移（CEST）-MRI）在心脏成像中的应用是可取的。然而，常规方法不适用于心脏成像，尤其是在具有快速心律的小型动物中。我们开发了一种CEST编码的稳态和回顾性门控心脏电影成像序列，其中纤维化或paraCEST造影剂的存在直接编码为稳态心肌信号强度（cardioCEST）。

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《Circulation. Cardiovascular imaging》 |2015年第1期|共15页
作者
Vandsburger Moriel; Vandoorne Katrien; Oren Roni; Leftin Avigdor; Mpofu Senzeni; Castelli Daniela Delli; Aime Silvio; Neeman Michal;
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正文语种 eng
中图分类诊断学;
关键词
magnetic resonance imaging; magnetization transfer contrast imaging; myocardial infarction;

机译：磁共振成像;磁化转移对比成像;心肌梗死;

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1. Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media [J] . Vandsburger Moriel, Vandoorne Katrien, Oren Roni, Circulation. Cardiovascular imaging . 2015,第1期

机译：心脏化学交换饱和转移磁共振成像揭示了内源性纤维化和外源性造影剂的分子特征
2. Osmotically Shrunken LIPOCEST Agents: An Innovative Class of Magnetic Resonance Imaging Contrast Media Based on Chemical Exchange Saturation Transfer [J] . Terreno E, Castelli DD, Violante E, Chemistry: A European journal . 2009,第6期

机译：渗透收缩的LIPOCEST剂：基于化学交换饱和转移的创新类磁共振成像造影剂
3. Imaging In Vivo Extracellular pH with a Single Paramagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agent [J] . Guanshu Liu, Yuguo Li, Vipul R. Sheth, Molecular imaging . 2012,第1期

机译：使用单个顺磁化学交换饱和成像磁共振成像造影剂对细胞外pH成像。
4. Transferrin-mediated tumor delivery of contrast media for optical imaging and magnetic resonance imaging [C] . Andreas Becker, Institut fuer Diagnostikforschung an der Freien Univ. Berlin, Berlin, Biomedical Imaging: Reporters, Dyes, and Instrumentation . 1999

机译：转铁蛋白介导的造影剂肿瘤递送，用于光学成像和磁共振成像
5. Magnetic Resonance Imaging of Paramagnetic Chemical Exchange Saturation Transfer Contrast Agents in Biological Systems. [D] . Li, Alex X. 2010

机译：生物系统中顺磁化学交换饱和转移造影剂的磁共振成像。
6. Using Two Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents for Molecular Imaging Studies [O] . M. MESER ALI, GUANSHU LIU, TEJAS SHAH, -1

机译：使用两种化学交换饱和转移磁性分子成像研究磁共振成像造影剂
7. Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media [O] . Moriel Vandsburger, Katrien Vandoorne, Roni Oren, 2015

机译：心脏化学交换饱和度转移磁共振成像显示内源性纤维化和外源造影剂的分子签名

Cardio-Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Reveals Molecular Signatures of Endogenous Fibrosis and Exogenous Contrast Media

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