Treatment of congestion in congestive heart failure: ultrafiltration is the only rational initial treatment of volume overload in decompensated heart failure.

Bart BA

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Treatment of congestion in congestive heart failure: ultrafiltration is the only rational initial treatment of volume overload in decompensated heart failure.

机译：充血性心力衰竭的充血治疗：超滤是失代偿性心力衰竭中容量超负荷的唯一合理初始治疗方法。

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The morbidity of decompensated heart failure is due to volume overload, a consequence of increased total body sodium.12 Failure to adequately reduce total body sodium contributes to progressive ventricular dysfunction, worsening heart failure, and excess morbidity. Ultrafiltration is the gold standard for sodium-volume removal and is the only intervention shown to improve outcomes in a randomized controlled trial of patients hospitalized with decompensated heart failure.3 Diuretics are inherently inferior because they produce hypotonic urine4-5and undesirable hemodynamic and neurohormonal changes.Therefore, ultrafiltration is the preferred initial treatment for patients hospitalized with de-compensated heart failure and sodium-volume overload.

机译：代偿性心力衰竭的发病率归因于体脂超负荷，这是体内总钠含量增加的结果。12不能充分降低体内总钠含量会导致进行性心室功能障碍，心力衰竭加重和发病率过高。超滤是去除钠量的金标准，并且是在失代偿性心力衰竭住院患者的随机对照试验中唯一能改善预后的干预措施。3利尿剂天生就较差，因为它们会产生低渗尿液4-5以及不良的血流动力学和神经激素变化。因此，对于失代偿性心力衰竭和钠容量超负荷住院的患者，超滤是首选的初始治疗。

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《Circulation. Heart failure》 |2009年第5期|共6页
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Bart BA;
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中图分类心脏、血管（循环系）疾病;
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1. Treatment of congestion in congestive heart failure: ultrafiltration is the only rational initial treatment of volume overload in decompensated heart failure. [J] . Bart BA Circulation. Heart failure . 2009,第5期

机译：充血性心力衰竭的充血治疗：超滤是失代偿性心力衰竭中容量超负荷的唯一合理初始治疗方法。
2. Design and rationale of the PROTECT study: a placebo-controlled randomized study of the selective A1 adenosine receptor antagonist rolofylline for patients hospitalized with acute decompensated heart failure and volume overload to assess treatment effect on congestion and renal function. [J] . Weatherley BD, Cotter G, Dittrich HC, Journal of cardiac failure . 2010,第1期

机译：PROTECT研究的设计和原理：一项针对急性失代偿性心力衰竭和容量超负荷住院患者的选择性A1腺苷受体拮抗剂rolofylline的安慰剂对照随机研究，以评估对充血和肾功能的治疗效果。
3. Ultrafiltration versus usual care for hospitalized patients with heart failure: the Relief for Acutely Fluid-Overloaded Patients With Decompensated Congestive Heart Failure (RAPID-CHF) trial. [J] . Bart BA, Boyle A, Bank AJ, Journal of the American College of Cardiology . 2005,第11期

机译：住院心力衰竭患者的超滤与常规护理：对失代偿性充血性心力衰竭的急性液体超负荷患者的缓解（RAPID-CHF）试验。
4. Rationale for Treatment of Heart Failure by Blockade of Ventricular Serotonin Receptors Appearing in Heart Failure [C] . E. Qvigstad -, T. Brattelid, I. Sjaasta International Society for Heart Research . 2005

机译：通过封锁心力衰竭出现的心室血清素受体治疗心力衰竭的理由
5. The Role of Tissue Modulus and Cardiac Fibroblast Phenotype in Volume Overload Induced Heart Failure. [D] . Childers, Rachel Caitlin. 2016

机译：组织模量和心脏成纤维细胞表型在超负荷导致心力衰竭中的作用。
6. Diuretic treatment in decompensated cirrhosis and congestive heart failure. [O] . A L Gerbes, R M Arendt 1986

机译：失代偿性肝硬化和充血性心力衰竭的利尿治疗。
7. Predictors of Postdischarge Outcomes From Information Acquired Shortly After Admission for Acute Heart Failure A Report From the Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function (PROTECT) Study [O] . Cleland, John G., Chiswell, Karen, Teerlink, John R., 2014

机译：急性心力衰竭入院后不久获得的信息可预测出院后的结果选择性A1腺苷受体拮抗剂Rolofylline的安慰剂对照随机研究报告为住院急性失代偿性心力衰竭和容量超负荷的患者提供评估，以评估对充血和肾的治疗效果功能（保护）研究

Treatment of congestion in congestive heart failure: ultrafiltration is the only rational initial treatment of volume overload in decompensated heart failure.

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