Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.

Lee HS; Lee TH; Yang SH; Shin HJ; Shin J; Oh KB

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Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.

机译：硫酸酯基萜烯酯作为热带海绵Hippospongia sp。的异柠檬酸裂解酶抑制剂。

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Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds 1 and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C(2) carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease.

机译：从热带海绵Hippospongia sp。中分离出了两种硫酸双酯（1-2）。评估了它们对稻瘟病菌Mgnaporthe grisea的异柠檬酸裂合酶（ICL）的抑制活性。通过水解化合物1获得化合物3。发现化合物1和3是有效的ICL抑制剂，可抑制稻瘟病菌的包膜形成和C（2）碳利用。我们的结果表明，ICL在稻瘟病菌的形成中起着至关重要的作用，并且是保护稻瘟病的新目标。

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《Bioorganic and Medicinal Chemistry Letters》 |2007年第9期|共4页
作者
Lee HS; Lee TH; Yang SH; Shin HJ; Shin J; Oh KB;
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正文语种 eng
中图分类药学;生物化学;
关键词
inhibitors; isocitrate; Porifera; Lyases; 多孔动物门; 裂合酶类;

机译：inhibitors;isocitrate;Porifera;Lyases;多孔动物门;裂合酶类;

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1. Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. [J] . Lee HS, Lee TH, Yang SH, Bioorganic and Medicinal Chemistry Letters . 2007,第9期

机译：硫酸酯基萜烯酯作为热带海绵Hippospongia sp。的异柠檬酸裂解酶抑制剂。
2. Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp. [J] . Lee D, Shin J, Yoon KM, Bioorganic and Medicinal Chemistry Letters . 2008,第20期

机译：来自热带海绵Dysidea sp。的硫酸酯基萜烯硫酸盐抑制白色念珠菌异柠檬酸裂解酶活性。
3. Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle [J] . Chan-Hong Ahn, Heegyu Kim, Jongheon Shin, Marine Drugs . 2014,第10期

机译：来自热带海绵球菌属的金黄色葡萄球菌的酯。在乙醛酸循环中抑制异柠檬酸裂合酶
4. Distribution and Abundance of Archaea in South China Sea Sponge Holoxea sp. and the Presence of Ammonia-Oxidizing Archaea in Sponge Cells [C] . Fang Liu, Minqi Han, Fengli Zhang, International Marine Biotechnology Conference . 2010

机译：南海海绵中的古细菌分布和丰富度Holoxea sp。和氨氧化古细菌在海绵细胞中的存在
5. Synthesis of Covalent Nitro Inhibitors of Mycobacterium tuberculosis Isocitrate Lyase [D] . You, Dai-Chi. 2020

机译：结核分枝杆菌异亚硝酸盐酶的共价硝基抑制剂的合成
6. Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle [O] . So-Hyoung Lee, Tae Hyung Won, Heegyu Kim, 2014

机译：来自热带海绵Coscinoderma sp。的Suvanine Sesterterpenes。在乙醛酸循环中抑制异柠檬酸裂解酶
7. Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle [O] . So-Hyoung Lee, Tae Hyung Won, Heegyu Kim, 2014

机译：suvanine sesterterpenes来自热带海绵Coscinoderma sp。抑制乙醛酸循环中的异柠檬酸裂解酶

Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.

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