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首页> 外文期刊>Journal of Applied Polymer Science >Novel Mucoadhesive Polymer Prepared by Template Polymerization of Acrylic Acid in the Presence of Silk Sericin
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Novel Mucoadhesive Polymer Prepared by Template Polymerization of Acrylic Acid in the Presence of Silk Sericin

机译：丝绸丝胶蛋白存在下丙烯酸模板聚合制备新型粘膜黏附聚合物

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摘要

A novel mucoadhesive polymer was prepared by template polymerization of acrylic acid in the presence of sericin for a transmucosal drug-delivery (TMD) system. FTIR results indicated that a polymer complex was formed between poly(acrylic acid) (PAA) and sericin through hydrogen bonding. The glass transition temperatures (T_g's) of sericin and PAA in the PAA/sericin polymer complex were inner-shifted compared with the T_g's of sericin and PAA themselves. This may be due to the increased miscibility of PAA with sericin through hydrogen bonding. The mucoadhesive force of the PAA/sericin polymer complex was similar to that of a commercial product, Carbopol 971P NF.
机译：一种新型的粘膜粘附性聚合物是通过在胶体蛋白存在下通过丙烯酸的模板聚合反应制备的，用于跨粘膜药物递送（TMD）系统。 FTIR结果表明，聚（丙烯酸）（PAA）和丝胶蛋白之间通过氢键形成了聚合物配合物。与丝胶和PAA本身的T_g相比，丝胶和丝胶聚合物复合物中丝胶和PAA的玻璃化转变温度（T_g）发生了内移。这可能是由于PAA与丝胶通过氢键的混溶性增加。 PAA / sericin聚合物复合物的粘膜粘附力与市售产品Carbopol 971P NF相似。

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