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首页> 外文期刊>Journal of Applied Polymer Science >Investigation of loading and release in PVA-based hydrogels
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Investigation of loading and release in PVA-based hydrogels

机译：基于PVA的水凝胶的负载和释放研究

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We used Methylene Blue (MB) and Methyl Orange (MO) as model drugs to investigate the controlled release behavior of hydrogels from poly(vinvl alcohol) crosslinked with ethylenediaminetetraacetic dianhydride. The cationic or anionic character of these compounds and the molecular weight between crosslinks of the hydrogel and the concentration of ionizable groups in the hydrogel greatly affected the loading and release of the drugs. MB loading was favored, therefore, by a higher content of negative charges in the hydrogel, although this implied a greater degree of crosslinking and, therefore, a lower mesh size. On the other hand, the overall loading of negative MO, favored by a higher mesh size, was very low because of unfavorable interactions with the electrolyte charges. Release studies showed that one of the parameters that most affected the drug release behavior of these hydrogels was the pH of the solution. MB and MO were not completely released, even at pH 1. (C) 2002 Wiley Periodicals, Inc. [References: 24]
机译：我们使用亚甲基蓝（MB）和甲基橙（MO）作为模型药物来研究与乙二胺四乙酸二酐交联的聚乙烯醇的水凝胶的控释行为。这些化合物的阳离子或阴离子特性以及水凝胶交联之间的分子量和水凝胶中可电离基团的浓度极大地影响了药物的负载和释放。因此，由于水凝胶中负电荷的含量较高，因此有利于MB负载，尽管这意味着更高程度的交联并因此具有较小的筛孔尺寸。另一方面，由于与电解质电荷的不利相互作用，负MO的总负载非常低，而较高的筛孔尺寸有利于此。释放研究表明，最影响这些水凝胶药物释放行为的参数之一是溶液的pH值。即使在pH值为1的情况下，MB和MO也不会完全释放。（C）2002 Wiley Periodicals，Inc. [参考：24]

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