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首页> 外文期刊>Journal of Applied Polymer Science >Production and characterization of poly(ethylene glycol dimethacrylate-styrene-glycidyl methacrylate) microbeads
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Production and characterization of poly(ethylene glycol dimethacrylate-styrene-glycidyl methacrylate) microbeads

机译：聚乙二醇二甲基丙烯酸酯-苯乙烯-甲基丙烯酸缩水甘油酯微珠的制备与表征

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Nonswellable and swellable poly(ethyleneglycol dimethacrylate)-based microbeads that could react directly with the biological molecules were produced by a suspension polymerization procedure. For this purpose, ethyleneglycol dimethacrylate (EGDMA) was copolymerized with glycidyl methacrylate (GMA) in an aqueous suspension medium. Benzoyl peroxide and poly(vinyl alcohol) were used as the initiator and the stabilizer, respectively. The copolymerization provided nonswellable, tranparent, and spherical copolymer microbeads in the size range of 100-300 mu m. On the other hand, swellable copolymer microbeads in the aqueous medium were obtained by using toluene as a diluent in the same copolymerization recipe. In a separate group of polymerizations, styrene (St) monomer was also included within the monomer phase to regulate the hydrophobicity of resulting microbeads. Nonswellable and swellable poly(EGDMA-St-CMA) microbeads were obtained by changing the type and concentration of the ingredients within the monomer phase. The effects of glycidyl methacrylate, styrene, and toluene concentrations on the microbead yield, the average size, and the swellability of microbeads were investigated. In the second part of the study, the interaction of produced microbeads with a selected enzyme (i.e., chymotrypsin) was investigated. The most stable chymotrypsin immobilization was achieved with the swellable poly(EGDMA)-based microbeads including styrene. (C) 1998 John Wiley & Sons, Inc. [References: 38]
机译：可以与生物分子直接反应的不可溶胀和可溶胀的聚（乙二醇二甲基丙烯酸乙二醇酯）基微珠是通过悬浮聚合法制备的。为此目的，将乙二醇二甲基丙烯酸酯（EGDMA）与甲基丙烯酸缩水甘油酯（GMA）在水性悬浮介质中共聚。过氧化苯甲酰和聚乙烯醇分别用作引发剂和稳定剂。共聚提供尺寸范围为100-300μm的不可溶胀的，透明的和球形的共聚物微珠。另一方面，在相同的共聚配方中，通过使用甲苯作为稀释剂，获得了水性介质中的可溶胀共聚物微珠。在另一组聚合中，苯乙烯（St）单体也包括在单体相中，以调节所得微珠的疏水性。通过改变单体相中成分的类型和浓度，获得不可溶胀和可溶胀的聚（EGDMA-St-CMA）微珠。研究了甲基丙烯酸缩水甘油酯，苯乙烯和甲苯浓度对微珠收率，平均尺寸和微珠溶胀性的影响。在研究的第二部分中，研究了产生的微珠与所选酶（即胰凝乳蛋白酶）的相互作用。最稳定的胰凝乳蛋白酶固定是通过可膨胀的基于聚（EGDMA）的微珠（包括苯乙烯）实现的。 （C）1998 John Wiley＆Sons，Inc. [参考：38]

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