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首页> 外文期刊>Journal of Applied Polymer Science >Specific sorbents for bilirubin removal from human plasma: Congo red modified poly(EGDMA/HEMA) microbeads
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Specific sorbents for bilirubin removal from human plasma: Congo red modified poly(EGDMA/HEMA) microbeads

机译：从人血浆中去除胆红素的特定吸附剂：刚果红改性聚（EGDMA / HEMA）微珠

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摘要

Congo Red-modified poly(EGDMA-HEMA) microbeads were investigated as a specific sorbent for bilirubin removal from human plasma. Poly(EGDMA-HEMA) microbeads were prepared by a modified suspension copolymerization technique. Congo Red was covalently incorporated into the poly(EGDMA-HEMA) microbeads via condensation reactions between the aromatic amine groups of the dyes and the hydroxyl groups of the HEMA, under alkaline conditions. Bilirubin adsorption was investigated from hyperbilirubinemic human plasma on the poly(EGDMA-HEMA) microbeads containing different amounts of attached Congo Red (between 2.5 and 14.6 mu mol/g). The nonspecific bilirubin adsorption on the unmodified poly(EGDMA-HEMA) microbeads were 0.32 mg/g from human plasma. High adsorption rates were observed at the beginning, and the adsorption equilibrium was then gradually achieved in about 30-60 min. Much higher bilirubin adsorption values, up to 11.7 mg/g, were obtained with the Congo Red-modified microbeads especially at 37 degrees C. The numbers (as mu mol) of bilirubin molecules to albumin molecules adsorbed on the sorbent microbeads were in the range of 15-20, which showed that bilirubin molecules were preferentially adsorbed to the Congo Red-modified microbeads. Bilirubin adsorption increased with increasing temperature. (C) 1998 John Wiley & Sons, Inc. [References: 40]
机译：研究了刚果红改性的聚（EGDMA-HEMA）微珠作为从人血浆中去除胆红素的特异性吸附剂。通过改进的悬浮共聚技术制备了聚（EGDMA-HEMA）微珠。在碱性条件下，通过染料的芳香胺基与HEMA的羟基之间的缩合反应，将刚果红共价掺入聚（EGDMA-HEMA）微珠中。研究了从高胆红素血症人血浆中胆红素在聚（EGDMA-HEMA）微珠上的吸附情况，该微珠含有不同量的附着的刚果红（2.5至14.6μmol / g）。来自人血浆的非特异性胆红素在未修饰的聚（EGDMA-HEMA）微珠上的吸附量为0.32 mg / g。在开始时观察到高吸附速率，然后在约30-60分钟内逐渐达到吸附平衡。刚果红修饰的微珠，特别是在37摄氏度下，胆红素的吸附值更高，高达11.7 mg / g。胆红素分子相对于吸附在微珠上的白蛋白分子的数量（以微摩尔计）在此范围内。 15-20的结果表明胆红素分子优先吸附到刚果红修饰的微珠上。胆红素的吸附随着温度的升高而增加。 （C）1998 John Wiley＆Sons，Inc. [参考：40]

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