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首页> 外文期刊>Journal of Applied Polymer Science >Amphiphilic urethane acrylate hydrogels: pH sensitivity and drug-releasing behaviors
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Amphiphilic urethane acrylate hydrogels: pH sensitivity and drug-releasing behaviors

机译：两亲氨基甲酸酯丙烯酸酯水凝胶：pH敏感性和药物释放行为

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摘要

Amphiphilic urethane acrylate hydrogels containing ionic groups (dimethylolpropionic acid, DMPA) were prepared with varying the molecular weight of the hydrophobic segment (polyether type, PTMG), and their swelling and drug-releasing behaviors were examined. Amphiphilic property for the hydrogels could be confirmed by observing the swelling in both water and organic solvent (benzene) readily. High pH sensitivity was observed due to the carboxylic groups incorporated into the molecular backbone of the urethane acrylate molecules. Owing to the amphiphilic property, it was possible to load hydrophilic (riboflavin selected) and hydrophobic (indomethacin selected) drugs in the network with ease. Each drug successfully released from the network of the urethane acrylate. The releasing behaviors were dependent upon the swelling ones and followed Fickian diffusion.
机译：制备具有离子基团的二亲氨基甲酸酯丙烯酸酯水凝胶（二羟甲基丙酸，DMPA），改变疏水链段的分子量（聚醚型，PTMG），并研究其溶胀和释药性能。通过容易观察在水和有机溶剂（苯）中的溶胀，可以确认水凝胶的两亲性。由于羧基结合到氨基甲酸酯丙烯酸酯分子的分子主链中，因此观察到高pH敏感性。由于具有两亲性质，可以轻松地在网络中加载亲水性药物（选择核黄素）和疏水性药物（选择吲哚美辛）。每种药物均已成功从氨基甲酸酯丙烯酸酯网络中释放出来。释放行为取决于溶胀行为并遵循菲克扩散。

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