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首页> 外文期刊>Circulation: An Official Journal of the American Heart Association >Use of an inspiratory impedance valve improves neurologically intact survival in a porcine model of ventricular fibrillation.
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Use of an inspiratory impedance valve improves neurologically intact survival in a porcine model of ventricular fibrillation.

机译：在猪的心室纤颤模型中，使用吸气阻抗阀可改善神经学上完整的存活率。

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摘要

BACKGROUND: This study evaluated the potential for an inspiratory impedance threshold valve (ITV) to improve 24-hour survival and neurological function in a pig model of cardiac arrest. METHODS AND RESULTS: Using a randomized, prospective, and blinded design, we compared the effects of a sham versus active ITV on 24-hour survival and neurological function. After 6 minutes of ventricular fibrillation (VF), followed by 6 minutes of cardiopulmonary resuscitation (CPR) with either a sham or an active valve, anesthetized pigs received 3 sequential 200-J shocks. If VF persisted, they received epinephrine (0.045 mg/kg), 90 seconds of CPR, and 3 more 200-J shocks. A total of 11 of 20 pigs (55%) in the sham versus 17 of 20 (85%) in the active valve group survived for 24 hours (P<0.05). Neurological scores were significantly higher with the active valve; the cerebral performance score (1=normal, 5=brain death) was 2.2+/-0.2 with the sham ITV versus 1.4+/-0.2 with the active valve (P<0.05). A total of 1 of 11 in the sham versus 12 of 17 in the active valve group had completely normal neurological function (P<0.05). Peak end-tidal CO2 (PETCO2) values were significantly higher with the active valve (20.4+/-1.0) than the sham (16.8+/-1.5) (P<0.05). PETCO2 >18 mm Hg correlated with increased survival (P<0.05). CONCLUSIONS: Use of a functional ITV during standard CPR significantly improved 24-hour survival rates and neurological recovery. PETCO2 and systolic blood pressure were also significantly higher in the active valve group. These data support further evaluation of ITV during standard CPR.
机译：背景：这项研究评估了在心脏骤停的猪模型中使用吸气阻抗阈值阀（ITV）改善24小时生存和神经功能的潜力。方法和结果：采用随机，前瞻性和盲法设计，我们比较了假手术和主动ITV对24小时生存率和神经功能的影响。心室纤颤（VF）6分钟，然后用假手术或主动瓣膜进行心肺复苏（CPR）6分钟后，麻醉猪连续3次受到200-J电击。如果VF持续存在，他们将接受肾上腺素（0.045 mg / kg），90秒的CPR和3次200-J的电击。假手术组中的20头猪中有11头（55％）与活动瓣膜组中的20头中的17头（85％）存活了24小时（P <0.05）。主动瓣膜的神经系统评分明显更高;假ITV的脑功能评分（1 =正常，5 =脑死亡）为2.2 +/- 0.2，而活动瓣膜为1.4 +/- 0.2（P <0.05）。假手术组中11例中有1例，活动瓣膜组中17例中有12例具有完全正常的神经功能（P <0.05）。主动瓣膜（20.4 +/- 1.0）的潮气末CO2（PETCO2）峰值显着高于假瓣膜（16.8 +/- 1.5）（P <0.05）。 PETCO2> 18 mm Hg与存活率增加相关（P <0.05）。结论：在标准心肺复苏期间使用功能性ITV可显着提高24小时生存率和神经功能恢复。活动瓣膜组的PETCO2和收缩压也显着升高。这些数据支持对标准CPR期间ITV的进一步评估。

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