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首页> 外文期刊>Journal of applied toxicology >Subchronic toxicity of PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) in rats.
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Subchronic toxicity of PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) in rats.

机译：PCB 105（2,3,3'，4,4'-五氯联苯）对大鼠的亚慢性毒性。

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The toxicity of 2,3,3',4,4'-pentachlorobiphenyl (PCB 105) was investigated in Sprague-Dawley rats following dietary exposure to this substance at levels of 0, 0.05, 0.5, 5 or 50 ppm for 13 weeks. Growth rate and food consumption were not affected and no clinical signs of toxicity were observed. Increased incidences of enlarged, fatty liver and decreased thymic weight were observed in the highest-dose groups of both genders; these groups also had elevated hepatic microsomal ethoxyresorufin deethylase activity and uroporphyrin. Significant increases in serum cholesterol and hepatic pentoxyresorufin dealkylase activity were observed in the highest-dose males and two highest-dose females. By contrast, liver UDP-glucuronosyl transferase activity was elevated in the two highest-dose males and the highest-dose females. Urinary ascorbic acid excretion was increased in the highest-dose males. While the amount of vitamin A was decreased dose-dependently, starting at 0.5 ppm in the liver of both sexes and in the lung of the females, the level in the kidney of the highest-dose group was increased. Administration of PCB 105 resulted in decreased dopamine in the caudate nucleus region of the brain in males and homovanillic acid in caudate nucleus and nucleus accumbens of females. Increased 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were observed in the substantia nigra region of both sexes, with most of the increases being seen in highest-dose females. Anemia, characterized by decreased hemoglobin, hematocrit and red cell indices, occurred in the highest-dose group, as did eosinophilia. Treatment with PCB 105 caused dose-dependent histopathological changes in the liver and thyroid. Thymic changes were observed in the highest-dose males and two highest-dose females. Tissue residue data showed a dose-dependent accumulation of this congener in fat, liver and spleen, kidney and brain. Based on these data the no-observable-effect level of PCB 105 was judged to be 0.05 ppm or 3.9 microg kg(-1) body wt. day(-1) in males and 4.2 microg kg(-1) body wt. day(-1) in females.
机译：在饮食中，以0、0.05、0.5、5或50 ppm的浓度暴露13周后，在Sprague-Dawley大鼠中研究了2,3,3'，4,4'-五氯联苯（PCB 105）的毒性。生长速度和食物消耗没有受到影响，也没有观察到毒性的临床迹象。在两个性别的最高剂量组中，脂肪肝增大和胸腺重量降低的发生率增加。这些组还具有较高的肝微粒体乙氧基间苯二酚脱乙基酶活性和尿卟啉。在最高剂量的雄性和两名最高剂量的雌性中观察到血清胆固醇和肝五氧苯磺酰脲脱烷基酶活性显着增加。相比之下，在两名最高剂量的雄性和最高剂量的雌性中，肝UDP-葡萄糖醛酸转移酶活性升高。剂量最高的男性尿中抗坏血酸排泄增加。尽管维生素A的剂量呈剂量依赖性地降低，从男女两性肝脏和女性肺中的0.5 ppm开始，最高剂量组的肾脏中的维生素A水平却增加了。施用PCB 105导致男性大脑尾状核区域的多巴胺减少，女性尾状核和伏隔核的高香草酸减少。在男女两性黑质区观察到5-羟色胺和5-羟吲哚乙酸的增加，其中大多数增加发生在剂量最高的女性中。贫血的特征是血红蛋白，血细胞比容和红细胞指数降低，最高剂量组与嗜酸性粒细胞增多症一样。用PCB 105进行治疗会引起肝脏和甲状腺的剂量依赖性组织病理学改变。在最高剂量的雄性和两个最高剂量的雌性中观察到胸腺变化。组织残留数据显示该同类物在脂肪，肝，脾，肾和脑中的剂量依赖性积累。根据这些数据，将PCB 105的不可观察到的水平判断为0.05 ppm或3.9 microg kg（-1）体重。男性每天（-1）和体重4.2微克kg（-1）。女性的day（-1）。

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