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首页> 外文期刊>Journal of applied toxicology >Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts.
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Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts.

机译：海藻提取物预防黄曲霉毒素B1诱导的大鼠肝毒性。

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摘要

Chemoprevention by extracts of Laurencia obtusa (E1) and Caulerpa prolifera (E2) collected from the Egyptian coast of the Red Sea against aflatoxin B(1) (AFB(1))-initiated hepatotoxicity in female Sprague-Dawley rats has been studied. Animals were fed aflatoxin-contaminated diet (3 mg kg(-1) diet) for 6 days then treated orally with pure aflatoxin B(1) (AFB(1)) (200 microg kg(-1) b.w.) for 4 days either in combination with or before E1 or E2 administration (50 mg kg(-1) b.w.). AFB(1) resulted in a signicant increase in serum alpha fetoprotein, carcinoembryonic antigen, tumor necrosis factor alpha, nitric oxide, interleukin-1alpha, procollagen III and lipid peroxidation level in the liver. It caused a signicant decrease in food intake, body weight, serum leptin, the activities of glutathione peroxidase, superoxide dismutase and DNA and RNA concentrations in the liver. Cotreatment with AFB(1) and E1 or E2 resulted in an obvious improvement in all tested parameters. Noteworthy, E2 was more effective than E1 in the protection against AFB(1)-induced hepatotoxicity.
机译：研究了从红海埃及海岸收集的Laurencia obtusa（E1）和Caulerpa prolifera（E2）提取物对黄曲霉毒素B（1）（AFB（1））引发的雌性Sprague-Dawley大鼠的肝毒性的化学预防作用。给动物饲喂受黄曲霉毒素污染的饮食（3 mg kg（-1）饮食）6天，然后用纯黄曲霉毒素B（1）（AFB（1））（200 microg kg（-1）bw）口服治疗4天与E1或E2给药之前或之前（50 mg kg（-1）bw）联合使用。 AFB（1）导致肝脏中血清甲胎蛋白，癌胚抗原，肿瘤坏死因子甲，一氧化氮，白介素-1α，前胶原III和脂质过氧化水平显着增加。它导致食物摄入，体重，血清瘦素，谷胱甘肽过氧化物酶，超氧化物歧化酶以及肝脏中DNA和RNA浓度的显着下降。与AFB（1）和E1或E2的共处理导致所有测试参数的明显改善。值得注意的是，在针对AFB（1）诱导的肝毒性的保护中，E2比E1更有效。

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