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首页> 外文期刊>Journal of applied toxicology >Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats.
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Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats.

机译：积雪草对砷诱导的大鼠氧化应激和金属分布的影响。

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Concomitant oral supplementation of Centella asiatica (100, 200 or 300 mg kg(-1), orally once daily) during arsenic exposure (20 ppm in drinking water for 4 weeks) was investigated in rats for its protective value. The animals exposed to arsenic (III) showed a significant inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity, a marginal decrease in glutathione (GSH) and an increase in zinc protoporphyrin (ZPP) level in blood. Hepatic and renal glutathione (GSH) decreased, while oxidized glutathione (GSSG) and thiobarbituric acid reactive substance (TBARS) levels increased significantly in the liver, kidney and brain. The activities of brain superoxide dismutase (SOD) and catalase decreased marginally on arsenic exposure. Concomitant administration of Centella asiatica showed a significant protective action on inhibited blood ALAD activity and restored the blood GSH level, whereas most of the other blood biochemical parameters remained unchanged on Centella asiatica supplementation. Interestingly, most of the hepatic biochemical variables indicative of oxidative stress showed protection. There was, however, a significant protection observed in the altered kidney GSSG level and hepatic and brain TBARS. Only a marginal beneficial effect of Centella asiatica on blood and liver arsenic concentration was noted, particularly at the highest dose studies (300 mg kg(-1)). No effect of Centella asiatica on most of the altered renal biochemical parameters was noted. The results thus lead to the conclusion that simultaneous supplementation of Centella asiatica significantly protects against arsenic-induced oxidative stress but does not influence the arsenic concentration in these organs. It can thus be suggested that co-administration of Centella asiatica protects animals from arsenic-induced oxidative stress but exhibits no chelating property. Further studies are recommended for determining the effect of co-administration of Centella asiatica during chelation therapy with a thiol chelator.
机译：研究了在大鼠中砷暴露（饮用水中20 ppm，持续4周）期间口服积雪草（100、200或300 mg kg（-1），每天口服一次）的保护价值。暴露于砷（III）的动物显示出显着抑制δ-氨基乙酰丙酸脱水酶（ALAD）活性，血液中谷胱甘肽（GSH）的少量降低和锌原卟啉（ZPP）水平的升高。肝，肾和脑中肝脏和肾脏的谷胱甘肽（GSH）降低，而氧化型谷胱甘肽（GSSG）和硫代巴比妥酸反应性物质（TBARS）的水平显着增加。暴露于砷后，脑超氧化物歧化酶（SOD）和过氧化氢酶的活性略有下降。积雪草的同时给药对抑制血液中的ALAD活性具有显着的保护作用，并恢复了血液中GSH的水平，而积雪草中的大多数其他血液生化指标保持不变。有趣的是，大多数指示氧化应激的肝脏生化变量均显示出保护作用。但是，在肾脏GSSG水平以及肝和脑TBARS改变中观察到了显着的保护作用。仅注意到积雪草对血液和肝脏砷浓度的边际有益作用，特别是在最高剂量研究（300 mg kg（-1））下。没有发现积雪草对大多数改变的肾脏生化参数有影响。结果因此得出结论，同时补充积雪草可显着保护砷诱导的氧化应激，但不影响这些器官中的砷浓度。因此可以提出，积雪草的共同给药可保护动物免受砷诱导的氧化应激的影响，但不表现出螯合特性。建议进行进一步研究，以确定在与硫醇螯合剂进行螯合治疗期间共同施用积雪草的效果。

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