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首页> 外文期刊>Journal of applied toxicology >The effect of adrenomedullin on rats exposed to lead.
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The effect of adrenomedullin on rats exposed to lead.

机译：肾上腺髓质素对暴露于铅的大鼠的影响。

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Adrenomedullin (AdM) was originally discovered as a vasorelaxant peptide. The antioxidative properties of AdM have been reported recently. Through its antioxidative effect, adrenomedullin can protect organs from damage induced by stressors. Lead, commonly detected in air, soil, water and food, is a major source of oxidative stress. The effect of AdM in the liver of rats exposed to lead was investigated. Twenty-four female Wistar rats were divided into four groups: a control group (C), adrenomedullin group (AdM), lead (Pb) group and lead + adrenomedullin (Pb + AdM) group. In the Pb-treated groups, the animals were exposed to lead in drinking water containing 250 ppm PbCl2 for 4 weeks. In the AdM-treated group, the animals received an i.p. injection of AdM (3000 ng kg(-1) body weight) in the third week of lead treatment for 1 week. The activities of catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and the level of malondialdehyde (MDA) were determined in the liver of rats. Histological changes in the liver were examined by light and electron microscopy as well. The MDA levels were increased significantly in the Pb-treated groups, but in the Pb + AdM group the MDA levels were decreased significantly when compared with the Pb group. AdM reduced hepatic damage in the Pb + AdM group, but the difference in the total histopathological scores between the Pb and Pb + AdM groups was not significant. When the results are taken together, it can be concluded that AdM may have protective or compensating effects in lead toxicity.
机译：肾上腺髓质素（AdM）最初是作为血管松弛素肽发现的。最近已经报道了AdM的抗氧化特性。通过其抗氧化作用，肾上腺髓质素可以保护器官免受应激源的损害。铅通常在空气，土壤，水和食物中被发现，是氧化应激的主要来源。研究了AdM在暴露于铅的大鼠肝脏中的作用。 24只雌性Wistar大鼠分为四组：对照组（C），肾上腺髓质素组（AdM），铅（Pb）组和铅+肾上腺髓质素（Pb + AdM）组。在用铅处理的组中，将动物暴露于含250 ppm PbCl2的饮用水中的铅4周。在用AdM治疗的组中，动物接受了腹腔注射。在铅治疗的第三周内注射AdM（3000 ng kg（-1）体重），持续1周。测定大鼠肝脏中过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）的活性以及丙二醛（MDA）的水平。肝脏的组织学变化也通过光学和电子显微镜检查。 Pb处理组的MDA水平显着增加，但Pb + AdM组的MDA水平与Pb组相比显着下降。 AdM减轻了Pb + AdM组的肝损伤，但Pb和Pb + AdM组之间的总组织病理学评分差异不显着。综合考虑结果，可以得出结论，AdM可能对铅毒性具有保护或补偿作用。

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