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首页> 外文期刊>Journal of applied toxicology >Cadmium chloride exposure modifies amino acid daily pattern in the mediobasal hypothalamus in adult male rat.
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Cadmium chloride exposure modifies amino acid daily pattern in the mediobasal hypothalamus in adult male rat.

机译：氯化镉暴露会改变成年雄性大鼠中下丘脑下丘脑的氨基酸每日模式。

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摘要

The present study was conducted to investigate the possible effects of cadmium exposure on the daily pattern of aspartate, glutamate, glutamine, gamma-aminobutyric acid (GABA) and taurine levels in the mediobasal hypothalamus of adult male rats. For this purpose, animals were treated with cadmium at two different exposure doses (25 and 50 mg l(-1) of cadmium chloride, CdCl(2)) in the drinking water for 30 days. Control age-matched rats received CdCl(2)-free water. After the treatment, rats were killed at six different time intervals throughout a 24 h cycle. CdCl(2) exposure modified the amino acid daily pattern, as it decreased aspartate, glutamate, GABA and taurine levels at 12:00 h with both exposure doses employed. In addition, the treatment with 25 mg l(-1) of CdCl(2) induced the appearance of minimal values at 16:00 h and maximal values between 04:00 and 08:00 h for glutamate, and a peak of glutamine content at 20:00 h. The heavy metal also decreased GABA medium levels around the clock in the mediobasal hypothalamus. However, CdCl(2) did not alter the metabolic correlation between glutamate, aspartate, glutamine and GABA observed in control animals. These results suggest that CdCl(2) induced several alterations in aspartate, glutamate, glutamine, GABA and taurine daily pattern in the mediobasal hypothalamus and those changes may be related to alterations in hypothalamic function.
机译：本研究旨在研究成年雄性大鼠下中下丘脑中镉暴露对天门冬氨酸，谷氨酸，谷氨酰胺，γ-氨基丁酸（GABA）和牛磺酸水平的日变化的可能影响。为此，在饮用水中以两种不同的暴露剂量（25和50 mg l（-1）的氯化镉，CdCl（2））用镉处理动物30天。对照年龄匹配的大鼠接受无CdCl（2）的水。治疗后，在整个24小时的周期内以六个不同的时间间隔杀死大鼠。 CdCl（2）暴露修改了氨基酸的每日模式，因为使用两种暴露剂量，它在12:00 h均降低了天冬氨酸，谷氨酸，GABA和牛磺酸的水平。此外，用25 mg l（-1）的CdCl（2）处理可导致在16:00 h出现最小值，在04:00到08:00 h出现最大值，谷氨酰胺含量达到峰值在20:00 h重金属也使中下丘脑全天降低GABA中等水平。但是，CdCl（2）不会改变在对照动物中观察到的谷氨酸，天冬氨酸，谷氨酰胺和GABA之间的代谢相关性。这些结果表明，CdCl（2）在中下丘脑下丘脑中诱导了天冬氨酸，谷氨酸，谷氨酰胺，GABA和牛磺酸每日模式的几种改变，这些改变可能与下丘脑功能的改变有关。

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