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首页> 外文期刊>Journal of applied toxicology >Genotoxic effects of (-)-cubebin in somatic cells of mice.
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Genotoxic effects of (-)-cubebin in somatic cells of mice.

机译：（-）-立方蛋白在小鼠体细胞中的遗传毒性作用。

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摘要

(-)-Cubebin belongs to the dibenzylbutyrolactone lignan group, which is widely distributed in the plant kingdom. Because this compound shows interesting biological activities, it is extremely important to evaluate its possible genotoxic activity to allow its safe use in humans. Thus, the present study was performed to investigate the genotoxicity potential activity of (-)-cubebin assessed by two assays: micronucleus in bone marrow cells and comet test in peripheral blood leukocytes of Swiss mice. In the (-)-cubebin dose range-finding assays, the maximum tolerated dose was greater than 2000 mg kg(-1) . The compound was administered by an oral route at single doses of 250, 500 and 2000 mg kg(-1) body weight. Cytotoxicity was assessed by scoring 200 consecutive total polychromatic (PCE) and normochromatic (NCE) erythrocytes (PCE/NCE ratio). Under our experimental conditions, micronucleus and comet assays, respectively, showed that (-)-cubebin caused dose-related clastogenic and genotoxic effects in the somatic cells investigated. PCE/NCE ratio showed no cytotoxicity for the three doses of the compound. The data suggest caution in the ingestion of (-)-cubebin by humans, especially at high doses. Copyright (c) 2010 John Wiley & Sons, Ltd.
机译：（-）-Cubebin属于在植物界广泛分布的二苄基丁内酯木脂素基团。由于该化合物显示出令人感兴趣的生物学活性，因此评估其可能的遗传毒性活性以使其在人类中安全使用非常重要。因此，进行本研究以研究通过两种测定法评估的（-）-立方素的潜在遗传毒性：瑞士小鼠的骨髓细胞中的微核和外周血白细胞中的彗星试验。在（-）-方筒剂量范围测定法中，最大耐受剂量大于2000 mg kg（-1）。该化合物通过口服途径以250、500和2000 mg kg（-1）体重的单剂量给药。通过对200个连续的总多色（PCE）和常色（NCE）红细胞（PCE / NCE比）进行评分，来评估细胞毒性。在我们的实验条件下，微核试验和彗星试验分别表明，（-）-立方蛋白在所研究的体细胞中引起了剂量相关的裂解和遗传毒性作用。对于三种剂量的化合物，PCE / NCE比均显示无细胞毒性。数据表明，在人类摄入（-）-立方蛋白时要特别小心，尤其是在高剂量下。版权所有（c）2010 John Wiley＆Sons，Ltd.

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