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首页> 外文期刊>Journal of applied toxicology >Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice
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Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice

机译：柠檬草（Cymbopogon citratus STAPF）精油对雌性Balb / C小鼠DNA损伤和致癌作用的保护作用

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摘要

This study investigated the protective effect of oral treatment with lemongrass (Cymbopogon citratus STAPF) essential oil (LGEO) on leukocyte DNA damage induced by W-methyl-W-nitrosurea (MNU). Also, the anticarcinogenic activity of LGEO was investigated in a multi-organ carcinogenesis bioassay induced by 7,12-dimethylbenz(a)antracene, 1,2-dimethylhydrazine and /V-butyl-/V-(4-hydroxibuthyl)nitrosamine in Balb/C female Balb/c mice (DDB-initiated mice). In the short-term study, the animals were allocated into three groups: vehicle group (negative control), MNU group (positive control) and LGEO 500 mg kg1 (five times per week for 5 weeks) plus MNU group (test group). Blood samples were collected to analyze leukocyte DNA"damage by comet assay 4 h after each MNU application at the end of weeks 3 and 5. The LGEO 500 mg kg ' treated group showed significantly lower (P < 0.01) leukocyte DNA damage than its respective positive group exposed to MNU alone at week 3. In the medium-term study, DDB-initiated mice were allocated into three groups: vehicle group (positive control) and LGEO 125 or 500 mg kg1 (five times per week for 6 weeks; test groups). At week 20, all animals were euthanized and mammary glands, colon and urinary bladder were processed for histopathological analyses for detection of preneoplastic and neoplastic lesions. A slight non-significant effect of treatment with LGEO 500 mg kg"1 in reducing development of alveolar and ductal mammary hyperplasia was found (P = 0.075). Our findings indicate that lemongrass essential oil provided protective action against MNU-induced DNA damage and a potential anticarcinogenic activity against mammary carcinogenesis in DDB-initiated female Balb/C mice. Copyright ? 2010 John Wiley & Sons, Ltd.
机译：这项研究调查了口服柠檬草（Cymbopogon citratus STAPF）精油（LGEO）对W-甲基-W-亚硝基脲（MNU）诱导的白细胞DNA损伤的保护作用。此外，LGE在Balb中由7,12-二甲基苯并（a）蒽，1,2-二甲基肼和/ V-丁基-/ V-（4-氢氧丁基）亚硝胺诱导的多器官致癌生物测定中研究了LGEO的抗癌活性。 / C雌性Balb / c小鼠（DDB启动的小鼠）。在短期研究中，将动物分为三组：媒介物组（阴性对照组），MNU组（阳性对照组）和LGEO 500 mg kg1（每周五次，连续5周）和MNU组（试验组）。在第3周和第5周结束时，每次MNU应用后4小时，收集血样以彗星分析法分析白细胞DNA的损伤。500 mg / kg LGEO处理组的白细胞DNA损伤明显低于其各自的（P <0.01）阳性组在第3周单独暴露于MNU。在中期研究中，将DDB引发的小鼠分为三组：媒介物组（阳性对照组）和LGEO 125或500 mg kg1（每周5次，共6周;测试）在第20周，对所有动物实施安乐死，并对乳腺，结肠和膀胱进行处理以进行组织病理学分析，以检测肿瘤前病变和肿瘤病变。使用LGEO 500 mg kg“ 1的治疗对减少发育有轻微的非显着性作用发现肺泡和导管乳腺增生（P = 0.075）。我们的发现表明，柠檬草精油在DDB引发的雌性Balb / C小鼠中提供了针对MNU诱导的DNA损伤的保护作用，以及针对乳癌发生的潜在抗癌活性。版权？ 2010 John Wiley＆Sons，Ltd.

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