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首页> 外文期刊>Journal of applied toxicology >Inorganic arsenite inhibits IgE receptor-mediated degranulation of mast cells.
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Inorganic arsenite inhibits IgE receptor-mediated degranulation of mast cells.

机译：无机亚砷酸盐可抑制IgE受体介导的肥大细胞脱粒。

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摘要

Millions of people worldwide are exposed to arsenic (As), a toxicant which increases the risk of various cancers, cardiovascular disease and several other health problems. Arsenic is a potent endocrine disruptor, including of the estrogen receptor. It was recently shown that environmental estrogen-receptor disruptors can affect the signaling of mast cells, which are important players in parasite defense, asthma and allergy. Antigen (Ag) or allergen crosslinking of IgE-bound receptors on mast cells leads to signaling, culminating in degranulation, the release of histamine and other mediators. Because As is an endocrine disruptor and because endocrine disruptors have been found to affect degranulation, here we have tested whether sodium arsenite affects degranulation. Using the rat basophilic leukemia (RBL) mast cell model, we have measured degranulation in a fluorescence assay. Arsenic alone had no effect on basal levels of degranulation. However, As strongly inhibited Ag-stimulated degranulation at environmentally relevant concentrations, in a manner that is very dependent on concentrations of both As and Ag. The concentrations of As effective at inhibiting degranulation were not cytotoxic. This inhibition may be a mechanism underlying the traditional Chinese medicinal use of As to treat asthma. These data indicate that As may inhibit the ability of humans to fight off parasitic disease.
机译：全世界有数百万人暴露于砷（As）中，砷是一种有毒物质，会增加罹患各种癌症，心血管疾病和其他一些健康问题的风险。砷是有效的内分泌干扰物，包括雌激素受体。最近显示，环境雌激素受体干扰物可以影响肥大细胞的信号传导，肥大细胞是寄生虫防御，哮喘和过敏的重要因素。肥大细胞上IgE结合受体的抗原（Ag）或过敏原交联会导致信号传导，最终导致脱粒，组胺和其他介质的释放。因为As是内分泌干扰物，并且因为发现内分泌干扰物会影响脱颗粒，所以在这里我们测试了亚砷酸钠是否会影响脱颗粒。使用大鼠嗜碱性粒细胞白血病（RBL）肥大细胞模型，我们已经在荧光测定法中测量了脱颗粒。单独的砷对基础脱颗粒水平没有影响。但是，在与环境有关的浓度下，砷强烈抑制了银刺激的脱粒，其方式非常依赖于砷和银的浓度。有效抑制脱粒的As浓度没有细胞毒性。这种抑制作用可能是中药As治疗哮喘的潜在机制。这些数据表明，砷可能会抑制人类抵抗寄生虫病的能力。

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