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首页> 外文期刊>Journal of applied toxicology >Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss-Webster mice.
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Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss-Webster mice.

机译：Swiss-Webster小鼠中功能化的单壁碳纳米管的生化和组织病理学评估。

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With their unique physicochemical properties, single-walled carbon nanotubes (SWCNTs) have many potential new applications in medicine and industry. A biomedical application of single-wall carbon nanotubes such as drug delivery requires a fundamental understanding of their fate and toxicological profile after administration. However, the toxicity of SWCNT is barely known when they are introduced into the blood circulation, which is especially vital for their biomedical applications. The aim of this study was to assess the effects, after intraperitoneal injection, of functionalized SWCNTs (carboxyl groups) on reactive oxygen species (ROS) induction and various hepatotoxicity markers (ALT, AST, ALP, LPO and morphology of liver) in the mouse model. We exposed mice to three different concentrations of functionalized SWCNTs (0.25, 0.5 and 0.75 mg kg(1) b.w.) and two controls (negative and positive). Samples were collected 24 h after the last treatment following standard protocols. Exposure to carboxylated functionalized SWCNT induced ROS and enhanced the activities of serum amino-transferases (ALT/AST) and alkaline phosphatases (ALP) and the concentration of lipid hydroperoxide compared with control. Histopathology of the exposed liver showed a statistically significant effect in the morphological alterations of the tissue compared with controls. The cellular findings reported here do suggest that purified carboxylated functionalized SWCNT has the potential to induce hepatotoxicity in Swiss-Webster mice through activation of the mechanisms of oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies. However, more studies to clarify the role of functionalization in the in vivo toxicity of SWCNTs are required and parallel comparison is preferred.
机译：单壁碳纳米管（SWCNT）凭借其独特的物理化学特性，在医学和工业领域具有许多潜在的新应用。单壁碳纳米管的生物医学应用，例如药物输送，需要对其给药后的命运和毒理学特征有基本的了解。但是，SWCNT进入血液循环时的毒性几乎是未知的，这对于它们的生物医学应用而言尤其重要。这项研究的目的是评估腹膜内注射后，功能化的SWCNT（羧基）对小鼠中活性氧（ROS）诱导和各种肝毒性标记物（ALT，AST，ALP，LPO和肝形态）的影响模型。我们将小鼠暴露于三种不同浓度的功能化SWCNT（0.25、0.5和0.75 mg kg（1）b.w.）和两个对照（阴性和阳性）。在最后处理24小时后，按照标准方案收集样品。与对照组相比，暴露于羧化功能化SWCNT诱导的ROS并增强了血清氨基转移酶（ALT / AST）和碱性磷酸酶（ALP）的活性以及脂质过氧化氢的浓度。与对照组相比，裸露的肝脏的组织病理学显示出组织形态改变具有统计学上的显着效果。此处报道的细胞发现确实表明，纯化的羧化功能化SWCNT有可能通过激活氧化应激的机制在Swiss-Webster小鼠中诱发肝毒性，这对保证体内动物暴露研究具有足够的意义。但是，需要更多的研究来阐明功能化在SWCNTs体内毒性中的作用，并且优选平行比较。

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