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首页> 外文期刊>Journal of applied toxicology >Exposure to chlorine gas: effects on pulmonary function and morphology in anaesthetised and mechanically ventilated pigs.
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Exposure to chlorine gas: effects on pulmonary function and morphology in anaesthetised and mechanically ventilated pigs.

机译：暴露于氯气中：对麻醉和机械通气猪的肺功能和形态的影响。

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摘要

We have examined the effects of chlorine gas inhalation (110 and 140 ppm) on cardiovascular and pulmonary function in nine anaesthetised and mechanically ventilated pigs. Four additional pigs, which were similarly treated but not exposed to gas, served as controls. Severe pulmonary dysfunction developed when the animals were exposed to 100 l of 140 ppm chlorine gas for 10 min. Five of six animals died within 6 h of exposure. This dose induced a rapid drop in arterial oxygen tension (P < 0.001 compared with controls, ANOVA), a biphasic decline in lung compliance (P < 0.001) and a gradual increase in pulmonary vascular resistance (P < 0.001) that eventually caused a significant reduction in cardiac output (P < 0.05). Microscopic examination showed sloughing of the bronchial epithelium and early infiltration with leukocytes, but largely intact alveoli. The sequence of events and the microscopic appearance suggested that the initial stage of pulmonary dysfunction (the first 1 or 2 h) was the result of mismatching of ventilation and perfusion. This was followed at a later stage by interstitial oedema and migration of immunocompetent cells into the tissue. We conclude that exposure to 100 l of 140 ppm chlorine gas induces a severe stereotypic lung injury with high mortality within 6 h in this anaesthetised animal model.
机译：我们检查了九种麻醉和机械通气的猪中，吸入氯气（110和140 ppm）对心血管和肺功能的影响。将另外四头经过类似处理但未暴露于气体的猪作为对照。将动物暴露于100升的140 ppm氯气中10分钟后，就会出现严重的肺功能障碍。六只动物中有五只在暴露后6小时内死亡。该剂量引起动脉血氧张力快速下降（与对照组相比，P <0.001，ANOVA），肺顺应性双相下降（P <0.001）和肺血管阻力逐渐增加（P <0.001），最终导致显着性心输出量降低（P <0.05）。镜检可见支气管上皮脱落和白细胞早期浸润，但肺泡基本​​完整。事件的顺序和微观外观表明，肺功能障碍的初始阶段（最初的1或2小时）是通气和灌注不匹配的结果。随后是间质性水肿和免疫活性细胞向组织的迁移。我们得出的结论是，在这种麻醉的动物模型中，暴露于100升的140 ppm氯气中会引起严重的定型性肺损伤，并在6小时内导致高死亡率。

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