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首页> 外文期刊>Journal of applied toxicology >Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice
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Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice

机译：早期慢性铅暴露会降低C57BL / 6J幼鼠的探索活动

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Research has suggested that chronic low-level lead exposure diminishes neurocognitive function in children. Tests that are sensitive to behavioral effects at lowest levels of lead exposure are needed for the development of animal models. In this study we investigated the effects of chronic low-level lead exposure on exploratory activity (unbaited nose poke task), exploratory ambulation (open field task) and motor coordination (Rotarod task) in pre-adolescent mice. C57BL/6J pups were exposed to 0 ppm (controls), 30 ppm (low-dose) or 230 ppm (high-dose) lead acetate via dams' drinking water administered from birth to postnatal day 28, to achieve a range of blood lead levels (BLLs) from not detectable to 14.84 mu g dl(-1)). At postnatal day 28, mice completed behavioral testing and were killed (n = 61). BLLs were determined by inductively coupled plasma mass spectrometry. The effects of lead exposure on behavior were tested using generalized linear mixed model analyses with BLL, sex and the interaction as fixed effects, and litter as the random effect. BLL predicted decreased exploratory activity and no threshold of effect was apparent. As BLL increased, nose pokes decreased. The C57BL/6J mouse is a useful model for examining effects of early chronic low-level lead exposure on behavior. In the C57BL/6J mouse, the unbaited nose poke task is sensitive to the effects of early chronic low-level lead exposure. This is the first animal study to show behavioral effects in pre-adolescent lead-exposed mice with BLL below 5 mu g dl(-1). Copyright (c) 2014 John Wiley & Sons, Ltd.
机译：研究表明，慢性低水平铅暴露会降低儿童的神经认知功能。建立动物模型需要在最低铅暴露水平下对行为影响敏感的测试。在这项研究中，我们调查了慢性低水平铅暴露对青春期前小鼠探索性活动（无诱饵的鼻子戳任务），探索性移动（开放野外任务）和运动协调（Rotarod任务）的影响。从出生到出生后第28天，通过大坝的饮用水将C57BL / 6J幼仔暴露于0 ppm（对照），30 ppm（低剂量）或230 ppm（高剂量）乙酸铅中，以获取一定范围的血铅浓度（BLLs）从不可检测到14.84μg dl（-1））。在出生后第28天，小鼠完成了行为测试并被处死（n = 61）。通过电感耦合等离子体质谱法测定BLL。铅暴露对行为的影响使用广义线性混合模型分析进行了测试，其中BLL，性别和相互作用为固定效应，凋落物为随机效应。 BLL预测探索活动减少，并且没有明显的作用阈值。随着BLL的增加，鼻子戳减少。 C57BL / 6J小鼠是用于检查早期慢性低水平铅暴露对行为影响的有用模型。在C57BL / 6J小鼠中，未诱饵的鼻子戳任务对早期慢性低水平铅暴露的影响敏感。这是第一个显示对BLL低于5μg dl（-1）的青春期前铅暴露小鼠的行为影响的动物研究。版权所有（c）2014 John Wiley＆Sons，Ltd.

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