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Animal models for percutaneous absorption

机译：经皮吸收的动物模型

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Animal models are important tools to predict human in vivo percutaneous absorption/penetration. Monkey, pig, rat, rabbit, guinea pig, hairless rodents, such as hairless rat, hairless mouse, hairless guinea pig and hairless dog, are among the most used animals for this purpose. Each animal model has its own advantages and weakness or limitation. To better correlate animal data with human skin absorption, we need to be familiar with each animal model's characteristics as well as experimental method and condition. We reviewed the original papers published after 1993 that described permeability of both animal skin and human skin. It showed that monkey, pig and hairless guinea pig are more predictive of human skin absorption/penetration and common laboratory animals, such as rat, rabbit, guinea pig, generally overestimate human skin absorption/penetration. Copyright (c) 2014 John Wiley & Sons, Ltd.
机译：动物模型是预测人体体内经皮吸收/渗透的重要工具。猴子，猪，大鼠，兔子，豚鼠，无毛啮齿动物，例如无毛大鼠，无毛小鼠，无毛豚鼠和无毛狗，是为此目的最常用的动物。每个动物模型都有其自身的优点和缺点或局限性。为了更好地将动物数据与人类皮肤吸收相关联，我们需要熟悉每种动物模型的特征以及实验方法和条件。我们回顾了1993年之后发表的描述动物皮肤和人类皮肤渗透性的原始论文。结果表明，猴子，猪和无毛豚鼠对人类皮肤吸收/穿透的预测性更高，而普通实验动物（如大鼠，兔子，豚鼠）通常会高估人类皮肤吸收/穿透的概率。版权所有（c）2014 John Wiley＆Sons，Ltd.

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