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首页> 外文期刊>Journal of applied toxicology >Effect of binge cocaine treatment on hindlimb vascular function.
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Effect of binge cocaine treatment on hindlimb vascular function.

机译：暴饮可卡因治疗对后肢血管功能的影响。

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Chronic cocaine abuse is known to cause endothelial dysfunction and atherosclerosis. The present study investigated the effect of binge cocaine treatment, a model for chronic cocaine abuse, on the blood flow responses to the adrenergic agonists norepinephrine, phenylephrine and isoproterenol, the endothelium-dependent vasodilator acetylcholine, and the endothelium independent vasodilator sodium nitroprusside (SNP) in the hindlimb vascular bed of male Sprague Dawley rats. Rats received either single binge or double binge treatment. Each binge treatment consisted of three doses of cocaine (30 mg kg(-1) i.p.) for 3 days. For double binge treatment, there was a 4 day recovery period between the binges. At the end of the treatment the rats were anesthetized and agonists were administered into the right hindlimb circulation through a catheter in the left iliac artery and blood flow responses were measured with a flow probe around the right iliac artery. Rats receiving double cocaine binges showed a significant decrease in the magnitude and duration of the blood flow response to norepinephrine and a decrease in the duration of the blood flow response to phenylephrine, isoproterenol and acetylcholine when compared with saline controls. The blood flow response to SNP was not changed. Total plasma nitrate-nitrite levels were significantly reduced and big endothelin levels were significantly increased in rats receiving double cocaine binges. This study demonstrates that binge cocaine treatment can alter endothelial function, while not changing smooth muscle function, and impairs the adrenergic pathway.
机译：已知长期滥用可卡因会引起内皮功能障碍和动脉粥样硬化。本研究调查了可卡因治疗（一种慢性可卡因滥用模型）对肾上腺素能激动剂去甲肾上腺素，去氧肾上腺素和异丙肾上腺素，内皮依赖性血管舒张剂乙酰胆碱和内皮依赖性血管舒张剂硝普钠（SNP）的血流反应的影响在雄性Sprague Dawley大鼠的后肢血管床中大鼠接受单暴食或双暴食治疗。每次暴食治疗均由三剂可卡因（30 mg kg（-1）i.p.）组成，持续3天。对于双暴饮暴食治疗，在两次发作之间有4天的恢复期。在治疗结束时，将大鼠麻醉，并通过左artery动脉中的导管将激动剂给药至右后肢循环中，并用绕probe右动脉的流量探针测量血流反应。与生理盐水对照组相比，接受双重可卡因暴食的大鼠对去甲肾上腺素的血流反应的幅度和持续时间显着减少，对苯肾上腺素，异丙肾上腺素和乙酰胆碱的血流反应的持续时间减少。对SNP的血流反应没有改变。在接受双可卡因暴食的大鼠中，血浆总硝酸盐-亚硝酸盐水平显着降低，大内皮素水平显着升高。这项研究表明，暴饮可卡因治疗可以改变内皮功能，而不会改变平滑肌功能，并削弱肾上腺素途径。

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