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首页> 外文期刊>Journal of applied toxicology >Effective bisquaternary reactivators of tabun-inhibited AChE.
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Effective bisquaternary reactivators of tabun-inhibited AChE.

机译：Tabun抑制的AChE的有效双季活化剂。

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摘要

Two cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun-inhibited acetylcholinesterase of the rat brain was tested in vitro. Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime and HI-6) were practically without reactivation potency. On the other hand, oximes K074, K075 and trimedoxime were satisfactorily effective. Moreover, K-oximes reactivated tabun-inhibited AChE at lower concentration (10(-4) and 10(-3) m) in comparison with trimedoxime (10(-3) and 10(-2) m). Thus, K-oximes can be considered as the most effective reactivators of tabun-inhibited AChE at present.
机译：合成了两种胆碱酯酶活化剂（K074和K075），并在体外测试了它们对禁忌素抑制的大鼠脑乙酰胆碱酯酶的活化作用。比较该功效表明，常用的肟（普利多辛，奥比多肟和HI-6）实际上没有再激活能力。另一方面，肟K074，K075和三ed肟令人满意。此外，与三聚肟（10（-3）和10（-2）m）相比，K-肟在较低的浓度（10（-4）和10（-3）m）下能重新激活塔宾抑制的AChE。因此，目前认为K-肟是禁忌素抑制的AChE最有效的活化剂。

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