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首页> 外文期刊>Journal of applied toxicology >Hair analysis by GC(sol )MS(sol )MS to verify abuse of drugs.
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Hair analysis by GC(sol )MS(sol )MS to verify abuse of drugs.

机译：通过GC（sol）MS（sol）MS进行头发分析，以验证药物滥用情况。

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Because of its peculiar characteristics, hair analysis provides a way of obtaining information that cannot be acquired by other commonly used forensic medical analyses, such as blood or urine analysis. In the keratin matrix many xenobiotics are incorporated permanently, in contrast to the situation with blood or urine where they are generally only detectable for a few hours or days. Therefore hair analysis should be the method of choice in the clinical and forensic toxicology field when the assessment of repeated or chronic exposure to a drug is required, e.g. in the case of criminal responsibility, revocation[sol ]restoration of a driving licence or in workplace testing.Some factors that can affect the concentrations of drugs in hair, such as passive contamination, age, ethnicity and cosmetic treatment, must be considered. Analytical methodology is also very important: GC[sol ]MS[sol ]MS has proved to be a highly sensitive and specific technique for the detection of very low concentrations of such drugs in hair. In this study five cases of the application of hair analyses using this technique for the determination of abused drugs (opiates, cocaine, amphetamine, anabolic steroids) are described. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：由于其独特的特性，头发分析提供了一种获取信息的方式，该信息无法通过其他常用的法医学分析（例如血液或尿液分析）获得。与通常只检测几个小时或几天的血液或尿液情况相反，许多异生物素在角蛋白基质中被永久掺入。因此，当需要评估重复或长期接触药物时，例如在临床和法医毒理学领域，头发分析应成为临床和法医毒理学领域的选择方法。在承担刑事责任的情况下，应撤销驾驶执照的恢复或在工作场所进行的测试。必须考虑一些会影响头发中药物浓度的因素，例如被动污染，年龄，种族和美容治疗。分析方法也非常重要：GC [sol] MS [sol] MS已被证明是检测头发中极低浓度此类药物的高度灵敏且特异的技术。在这项研究中，描述了使用这种技术测定滥用药物（鸦片，可卡因，苯丙胺，合成代谢类固醇）的五例案例。版权所有（c）2005 John Wiley＆Sons，Ltd.

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