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首页> 外文期刊>Journal of applied toxicology >Comparison of the hydrolytic stability of S-(N,N-diethylaminoethyl) isobutyl methylphosphonothiolate with VX in dilute solution.
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Comparison of the hydrolytic stability of S-(N,N-diethylaminoethyl) isobutyl methylphosphonothiolate with VX in dilute solution.

机译：比较S-（N，N-二乙基氨基乙基）异丁基甲基硫代磷酸硫酯与VX在稀溶液中的水解稳定性。

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摘要

The stability of S-(N,N-diethylaminoethyl) isobutyl methylphosphonothiolate--a V-type nerve agent developed by the former Soviet Union--in the environment is an important parameter in threat assessment analysis and for the determination of use, production, testing and storage of this chemical warfare agent. S-(N,N-Diethylaminoethyl) isobutyl methylphosphonothiolate is a structural isomer of the nerve agent VX developed by the USA and the UK and will be referred to as VXA (VX analog) in this presentation. Because VXA and VX differ structurally, even though they do have the same molecular formula, it is expected that their physical and chemical properties would be different. This preliminary investigation was undertaken to determine the relative hydrolysis rate of VXA compared with VX. The hydrolysis of each compound at approximately 1 mg x ml(-1) in unbuffered water at pH 7 was determined side-by-side. The half-lives for VXA and VX were determined to be 12.4 days and 4.78 days, respectively. Agent VXA hydrolyzed 2.6 times more slowly than VX, and each agent followed second-order hydrolysis kinetics. These results imply that VXA is more persistent in the environment and therefore poses a greater threat. These results also imply that VXA is more likely to be detected, if present, during an inspection in support of the Chemical Weapons Convention. Copyright 2001 John Wiley & Sons, Ltd.
机译：前苏联开发的V型神经毒药S-（N，N-二乙基氨基乙基）异丁基甲基硫代磷酸膦酯在环境中的稳定性是威胁评估分析以及确定使用，生产，测试和储存此化学战剂。 S-（N，N-二乙基氨基乙基）异丁基甲基硫代磷酸酯是美国和英国开发的神经毒剂VX的结构异构体，在本演示中将其称为VXA（VX类似物）。由于VXA和VX在结构上有所不同，即使它们具有相同的分子式，也可以预期它们的物理和化学性质会有所不同。进行该初步研究以确定VXA与VX的相对水解速率。并排测定了每种化合物在pH 7的非缓冲水中的大约1 mg x ml（-1）的水解。 VXA和VX的半衰期分别确定为12.4天和4.78天。 VXA试剂的水解速度比VX慢2.6倍，每种试剂均遵循二级水解动力学。这些结果表明，VXA在环境中更具持久性，因此构成了更大的威胁。这些结果还暗示，在支持《化学武器公约》的检查过程中，如果存在VXA，则更有可能被检测到。版权所有2001 John Wiley＆Sons，Ltd.

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