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首页> 外文期刊>Journal of applied toxicology >Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro.
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Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro.

机译：水杨酸苄酯，苯甲酸苄酯和丁基苯基甲基丙酸（Lilial）在人乳腺癌MCF7细胞中的成骨活性。

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摘要

Benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) are added to bodycare cosmetics used around the human breast. We report here that all three compounds possess oestrogenic activity in assays using the oestrogen-responsive MCF7 human breast cancer cell line. At 3 000 000-fold molar excess, they were able to partially displace [(3)H]oestradiol from recombinant human oestrogen receptors ERalpha and ERbeta, and from cytosolic ER of MCF7 cells. At concentrations in the range of 5 x 10(-5) to 5 x 10(-4 )m, they were able to increase the expression of a stably integrated oestrogen-responsive reporter gene (ERE-CAT) and of the endogenous oestrogen-responsive pS2 gene in MCF7 cells, albeit to a lesser extent than with 10(-8 )m 17beta-oestradiol. They increased the proliferation of oestrogen-dependent MCF7 cells over 7 days, which could be inhibited by the antioestrogen fulvestrant, suggesting an ER-mediated mechanism. Although the extent of stimulation of proliferation over 7 days was lower with these compounds than with 10(-8 )m 17beta-oestradiol, given a longer time period of 35 days the extent of proliferation with 10(-4 )m benzyl salicylate, benzyl benzoate or butylphenylmethylpropional increased to the same magnitude as observed with 10(-8 )m 17beta-oestradiol over 14 days. This demonstrates that benzyl salicylate, benzyl benzoate and butylphenylmethylpropional are further chemical components of cosmetic products which give oestrogenic responses in a human breast cancer cell line in culture. Further research is now needed to investigate whether oestrogenic responses are detectable using in vivo models and the extent to which these compounds might be absorbed through human skin and might enter human breast tissues.
机译：将水杨酸苄酯，苯甲酸苄酯和丁基苯基甲基丙酸酯（Lilial）添加到用于人乳房周围的身体护理化妆品中。我们在此报告，在使用雌激素反应性MCF7人乳腺癌细胞系的测定中，所有三种化合物均具有雌激素活性。在3 000 000倍摩尔过量时，它们能够从重组人雌激素受体ERalpha和ERbeta以及MCF7细胞的胞质ER中部分置换[（3）H]雌二醇。在5 x 10（-5）至5 x 10（-4）m的浓度范围内，它们能够增加稳定整合的雌激素反应性报告基因（ERE-CAT）和内源性雌激素-表达的表达。响应的pS2基因在MCF7细胞中，尽管程度比10（-8）m17β-雌二醇低。他们在7天之内增加了雌激素依赖性MCF7细胞的增殖，这可以被抗雌激素的氟维司群抑制剂抑制，表明是ER介导的机制。尽管这些化合物在7天内刺激增殖的程度低于10（-8）m17β-雌二醇，但在35天的较长时间范围内，水杨酸苄酯，苄基10（-4）m的增殖程度苯甲酸或丁基苯基甲基丙酸酯在14天内增加到与10（-8）m17β-雌二醇相同的幅度。这表明水杨酸苄酯，苯甲酸苄酯和丁基苯基甲基丙酸酯是化妆品的其他化学成分，其在培养的人类乳腺癌细胞系中产生雌激素反应。现在需要进行进一步的研究，以调查使用体内模型是否可以检测到雌激素反应，以及这些化合物可能被人体皮肤吸收并进入人体乳腺组织的程度。

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