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首页> 外文期刊>Journal of applied toxicology >Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats.
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Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats.

机译：氯菊酯在Endo III和Fpg部位均诱导淋巴细胞DNA损伤，并在大鼠单核细胞呼吸爆发中发生变化。

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摘要

Pyrethroids are widely used insecticides of low acute toxicity in mammals but the consequences of long-term exposure are of concern. Their insecticidal action is related to neurotoxicity and, in addition, there are indications of mammalian immuno-toxicity. In this work the effect of 60 days permethrin (150 mg kg(-1) body weight/day) exposure on two types of leukocytes (monocytes and lymphocytes) in adolescent rats was investigated. In particular, the monocyte respiratory burst response was first investigated, followed by studies on the degree and type of lymphocyte DNA damage induced by permethrin at this stage of life. Permethrin treatment reduces the monocyte respiratory burst response to phorbol myristate acetate, thereby decreasing superoxide anion (65%) and hydrogen peroxide (37%) production. Moreover an increase [correction made here after initial online publication] in monocyte plasma membrane fluidity in the hydrophilic-hydrophobic interface of the lipid bilayer was measured. Data obtained from the comet assay show that permethrin induces lymphocyte DNA lesions at both formamido pyrimidine glycosylase (Fpg) and endonuclease III (Endo III) sites in adolescent rats. Our results indicate the key role of permethrin in oxidative stress whose consequences lead to biochemical and functional changes. The reduced phagocyte respiratory burst induced by permethrin treatment and the type of DNA damage measured could represent new relevant aspects of pyrethroid toxicity which should be considered for human health.
机译：拟除虫菊酯是哺乳动物中急性毒性低的广泛使用的杀虫剂，但长期暴露的后果值得关注。它们的杀虫作用与神经毒性有关，此外，还有哺乳动物免疫毒性的迹象。在这项工作中，研究了60天氯菊酯（150 mg kg（-1）体重/天）暴露对青春期大鼠中两种类型的白细胞（单核细胞和淋巴细胞）的影响。特别是，首先研究了单核细胞呼吸爆发反应，然后研究了在此阶段由苄氯菊酯诱导的淋巴细胞DNA损伤的程度和类型。苄氯菊酯治疗可减少单药对肉豆蔻酸乙酸佛波酯的呼吸爆发反应，从而降低超氧阴离子（65％）和过氧化氢（37％）的产生。此外，还测量了脂质双层的亲水-疏水界面中单核细胞质膜流动性的增加[在首次在线发表后在此进行了校正]。从彗星试验获得的数据表明，苄氯菊酯在青春期大鼠的甲酰胺基嘧啶糖基化酶（Fpg）和内切核酸酶III（Endo III）部位均诱导淋巴细胞DNA损伤。我们的结果表明苄氯菊酯在氧化应激中的关键作用，其后果导致生化和功能变化。苄氯菊酯治疗引起的吞噬细胞呼吸爆发减少和所测量的DNA损伤类型可能代表拟除虫菊酯毒性的新的相关方面，应为人类健康考虑。

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