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首页> 外文期刊>Journal of applied toxicology >Derivation of temporary emergency exposure limits (TEELs).
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Derivation of temporary emergency exposure limits (TEELs).

机译：推导临时紧急暴露极限（TEEL）。

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Short-term chemical concentration limits are used in a variety of applications, including emergency planning and response, hazard assessment and safety analysis. Development of emergency response planning guidelines (ERPGs) and acute exposure guidance levels (AEGLs) are predicated on this need. Unfortunately, the development of peer-reviewed community exposure limits for emergency planning cannot be done rapidly (relatively few ERPGs or AEGLs are published each year). To be protective of Department of Energy (DOE) workers, on-site personnel and the adjacent general public, the DOE Subcommittee on Consequence Assessment and Protective Actions (SCAPA) has developed a methodology for deriving temporary emergency exposure limits (TEELs) to serve as temporary guidance until ERPGs or AEGLs can be developed. These TEELs are approximations to ERPGs to be used until peer-reviewed toxicology-based ERPGs, AEGL or equivalents can be developed. Originally, the TEEL method used only hierarchies of published concentration limits (e.g. PEL- or TLV-TWAs, -STELs or -Cs, and IDLHs) to provide estimated values approximating ERPGs. Published toxicity data (e.g. lc(50), lc(LO), ld(50) and ld(LO) for TEEL-3, and tc(LO) and td(LO) for TEEL-2) are included in the expanded method for deriving TEELs presented in this paper. The addition here of published toxicity data (in addition to the exposure limit hierarchy) enables TEELs to be developed for a much wider range of chemicals than before. Hierarchy-based values take precedence over toxicity-based values, and human toxicity data are used in preference to animal toxicity data. Subsequently, default assumptions based on statistical correlations of ERPGs at different levels (e.g. ratios of ERPG-3s to ERPG-2s) are used to calculate TEELs where there are gaps in the data. Most required input data are available in the literature and on CD ROMs, so the required TEELs for a new chemical can be developed quickly. The new TEEL hierarchy/toxicity methodology has been used to develop community exposure limits for over 1200 chemicals to date. The new TEEL methodology enables emergency planners to develop useful approximations to peer-reviewed community exposure limits (such as the ERPGs) with a high degree of confidence. For definitions and acronyms, see Appendix. Copyright 2000 Westinghouse Safety Management Solutions LLC obtained pursuant to US government contract.
机译：短期化学物浓度限值可用于多种应用，包括应急计划和响应，危害评估和安全分析。应急需求规划指南（ERPG）和急性暴露指导水平（AEGL）的开发是基于这种需要的。不幸的是，无法迅速完成同行评审的社区对应急计划的暴露限值的制定（每年很少发布ERPG或AEGL）。为了保护能源部（DOE）的工人，现场人员和邻近的公众，DOE后果评估和保护行动小组委员会（SCAPA）已开发出一种方法来推导临时的紧急暴露限值（TEEL），以用作临时指导，直到可以制定ERPG或AEGL。这些TEEL近似于要使用的ERPG，直到可以开发出经过同行评审的基于毒理学的ERPG，AEGL或等效产品为止。最初，TEEL方法仅使用已发布浓度极限的层次结构（例如PEL-或TLV-TWA，-STEL或-C和IDLH）来提供近似ERPG的估计值。扩展的方法包括已发布的毒性数据（例如，TEEL-3的lc（50），lc（LO），ld（50）和ld（LO）以及TEEL-2的tc（LO）和td（LO））本文推导的TEEL。在这里添加已发布的毒性数据（除了暴露限值层次结构之外），还可以开发TEEL，以用于比以前更广泛的化学品。基于层次结构的值优先于基于毒性的值，并且人类毒性数据优先于动物毒性数据使用。随后，基于ERPG在不同级别上的统计相关性（例如，ERPG-3与ERPG-2的比率）的默认假设用于计算数据中存在缺口的TEEL。文献和CD ROM上都提供了大多数所需的输入数据，因此可以快速开发出新化学品所需的TEEL。迄今为止，新的TEEL等级/毒性方法已用于制定社区对超过1200种化学物质的暴露限值。新的TEEL方法使应急计划制定者能够高度自信地开发出经过同行评审的社区接触限值（例如ERPG）的有用近似值。有关定义和首字母缩写，请参阅附录。版权2000西屋安全管理解决方案有限责任公司根据美国政府合同获得。

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