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首页> 外文期刊>Journal of applied toxicology >Hepatoprotective effects of syringin on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice
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Hepatoprotective effects of syringin on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice

机译：丁香脂素对D-半乳糖胺和脂多糖诱导的暴发性肝衰竭的小鼠肝保护作用

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摘要

The prognosis for fulminant hepatic failure (FHF) still remains extremely poor with a high mortality and, therefore, better treatments are urgently needed. Syringin, a main active substance isolated from Eleutherococcus senticosus, has been reported to exhibit immunomodulatory and anti-inflammatory properties. In this study, we investigated the effects and underlying mechanisms of syringin on lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced FHF in mice. Mice were administered syringin (10, 30 and 100mgkg-1, respectively) intraperitoneally (i.p) 30min before LPS/D-GalN then mortality and liver injury were evaluated subsequently. We found that syringin dose-dependently attenuated LPS/D-GalN-induced FHF, as indicated by reduced mortality, inhibited aminotransferase and malondialdehyde (MDA) content, an increased glutathione (GSH) concentration and alleviated pathological liver injury. In addition, syringin inhibited LPS/D-GalN-induced hepatic caspase-3 activation and hepatocellular apoptosis, myeloperoxidase (MPO) activity and intercellular adhesion molecule-1 (ICAM-1) expression, as well as hepatic tissues tumor necrosis factor-alpha (TNF-α) production and NF-κB activation in a dose-dependent manner. These experimental data indicate that syringin might alleviate the FHF induced by LPS/D-GalN through inhibiting NF-κB activation to reduce TNF-α production.
机译：暴发性肝衰竭（FHF）的预后仍然非常差，死亡率高，因此迫切需要更好的治疗方法。据报道，丁香叶素是从刺肠肠球菌中分离出来的主要活性物质，具有免疫调节和抗炎特性。在这项研究中，我们调查了丁香香精素对脂多糖（LPS）和D-半乳糖胺（D-GalN）诱导的小鼠FHF的影响及其潜在机制。在LPS / D-GalN注射前30分钟，腹膜内（i.p）给小鼠注射丁香香精素（分别为10、30和100mgkg-1），然后评估死亡率和肝损伤。我们发现紫丁香碱剂量依赖性地降低了LPS / D-GalN诱导的FHF，如降低的死亡率，抑制的氨基转移酶和丙二醛（MDA）含量，增加的谷胱甘肽（GSH）浓度以及减轻的病理性肝损伤所表明。此外，丁香香精素还抑制LPS / D-GalN诱导的肝caspase-3活化和肝细胞凋亡，髓过氧化物酶（MPO）活性和细胞间粘附分子1（ICAM-1）表达，以及肝组织肿瘤坏死因子-α（ TNF-α）的产生和NF-κB的激活呈剂量依赖性。这些实验数据表明，丁香香精素可能通过抑制NF-κB活化以减少TNF-α的产生而减轻LPS / D-GalN诱导的FHF。

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