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首页> 外文期刊>Journal of applied toxicology >T-helper cell-mediated factors in drug-induced liver injury
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T-helper cell-mediated factors in drug-induced liver injury

机译：T辅助细胞介导的因素在药物性肝损伤中的作用

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Drug-induced liver injury (DILI) leads to a large burden on the healthcare system due to its potential morbidity and mortality. The key for predicting and preventing DILI is to understand the underlying mechanisms. Hepatic inflammation is one of the most common features of DILI. The inflammation can be attributed to the innate immune response. The adaptive immune system is also affected by the innate immune response resulting in liver damage. T-helper cells are important regulators of acquired immunity. T-helper cell-mediated immune responses play pivotal roles in the pathogenesis of a variety of liver disorders. This review summarizes recent advances in the T-helper cell-mediated factors in DILI and potential mechanisms, which may lead to a better understanding of DILI. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：药物性肝损伤（DILI）由于其潜在的发病率和死亡率而给医疗保健系统带来了沉重负担。预测和预防DILI的关键是了解潜在的机制。肝炎是DILI最常见的特征之一。炎症可归因于先天免疫反应。适应性免疫系统还受到先天性免疫反应的影响，导致肝脏受损。 T辅助细胞是获得性免疫的重要调节剂。 T辅助细胞介导的免疫反应在多种肝病的发病机理中起关键作用。这篇综述总结了DILI中T辅助细胞介导的因子及其潜在机制的最新进展，这可能导致人们对DILI有了更好的了解。版权所有（c）2015 John Wiley＆Sons，Ltd.

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