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首页> 外文期刊>Circulation. Heart failure >Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial

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Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial

机译：针对肥厚型心肌病的复杂病理生理学的新方法有症状的肥厚型心肌病受试者接受后期钠电流抑制对运动能力的影响（LIBERTY-HCM）试验

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《Circulation. Heart failure》 |2016年第3期|共10页
作者
Olivotto Iacopo; Hellawell Jennifer L.; Farzaneh-Far Ramin; Blair Christiana; Coppini Raffaele; Myers Jonathan; Belardinelli Luiz; Maron Martin S.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
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1. Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial [J] . Olivotto Iacopo, Hellawell Jennifer L., Farzaneh-Far Ramin, Circulation. Heart failure . 2016,第3期

机译：针对肥厚型心肌病的复杂病理生理学的新方法有症状的肥厚型心肌病受试者接受后期钠电流抑制对运动能力的影响（LIBERTY-HCM）试验
2. Letter by Sikkel et al Regarding Article, "Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy" [J] . Sikkel Markus B., MacLeod Kenneth T., Gordon Fabiana Circulation: An Official Journal of the American Heart Association . 2013,第10期

机译：Sikkel等人关于文章的信函：“晚期钠电流抑制逆转了人类肥厚型心肌病的机电功能障碍”
3. Response to Letter Regarding Article, "Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy" [J] . Coppini Raffaele, Ferrantini Cecilia, Del Lungo Martina, Circulation: An Official Journal of the American Heart Association . 2013,第10期

机译：对有关文章“晚期钠电流抑制逆转人肥厚型心肌病的机电功能障碍”的信函的答复
4. Late sodium current inhibition counteracts pro-arrhythmic mechanisms in human hypertrophic cardiomyopathy [C] . Passini Elisa, Rodriguez Blanca, Minchole Ana, Computing in Cardiology Conference . 2014

机译：晚期钠电流抑制作用抵消了人类肥厚型心肌病的促心律失常机制
5. An assessment of determinants impacting genetic testing for hypertrophic cardiomyopathy [D] . Byrne, Lindsey 2008

机译：影响肥厚型心肌病基因检测的决定因素评估
6. Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium [O] . Cecilia Ferrantini, Josè Manuel Pioner, Luca Mazzoni, 2018

机译：晚期钠电流抑制剂治疗肥厚型心肌病运动性梗阻：人心肌的体外研究
7. HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel insights at a regional levelP162Pulmonary vascular capacitance as assessed by echocardiography in pulmonary arterial hypertensionP163Three-dimensional endocardial area strain: a novel parameter for quantitative assessment of global left ventricular systolic functionP164Role of exercise hemodynamics assessed by echocardiography on symptom reduction after MitraClipP165Early identification of ventricular dysfunction in patients with juvenile systemic sclerosisP166Heart failure with and without preserved ejection fraction - the role of biomarkers in the aspect of global longitudinal strainP167Complex systolic deformation of aortic root: insights from two dimensional speckle tracking imageP168Volumetric and deformational imaging usind 2d strain and 3d echocardiography in patients with pulmonary hypertensionP169Influence of pressure load and right ventricular morphology and function on tricuspid regurgitation in pulmonary arterial hypertensionP170Left ventricular myocardial diastolic deformation analysis by 2D speckle tracking echocardiography and relationship with conventional diastolic parameters in chronic aortic regurgitationP171Extracellular volume, and not native T1 time, distinguishes diffuse fibrosis in dilated or hypertrophic cardiomyopathy at 3TP172Left atrial strain is significantly reduced in arterial hypertensionP173Symptomatic severe secondary mitral regurgitation: LV enddiastolic diameter (LVEDD) as preferable parameter for risk stratificationP174Left ventricular mechanics in isolated left bundle branch block at rest and when exercising: exploration of the concept of conductive cardiomyopathyP175Assessment of myocardial scar by 2D contrast echocardiographyP176Chronic pericarditis - expression of a rare disease: Erdheim Chester diseaseP177Aortic arch mechanics with two-dimensional speckle tracking echocardiography to estimate the left ventricular remodelling in hypertensive patientsP178Strain analysis by tissue doppler imaging: comparison of conventional manual measurement with a semi-automated approachP179Distribution of extravascular lung water in heart failure patients assessed by lung ultrasoudP180Surrogate markers for obstructive coronary artery diseaseP181LA deformation and LV longitudinal strain by two-dimensional speckle tracking echocardiography as predictors of postoperative AF development after aortic valve replacement in ASP182Left ventricular diastolic dysfunction in type 2 diabetic patients with non alcoholic fatty liver diseaseP183Myocardial strain by speckle-tracking and evaluation of 3D ejection fraction in drug-induced cardiotoxicity's approach in breast cancer [O] . AB Gevaert, A Borizanova, F Graziani, 2015

机译：HIT墙报1P154Preclinical舒张功能障碍的慢性肾脏diseaseP155Early检测左心房的相关内皮功能受损，左心室异常，高血压和肥胖womenP156Right心室收缩功能正常，不论右心室肥厚和疾病严重程度在安德森法布里diseaseP157Left房容积和经皮二尖瓣修复患者的功能左心室功能障碍与自膨胀生物升降术患者患者患者的结果，来自超高帧速率组织多普勒成像的患者，用于评估缺血二尖瓣复发的组织变形P160平面动力学后在急性心肌梗死冠脉介入干预：从急诊室到三维超声心动图右心室体积的长期跟踪upP161Reproducibility串行超声心动图评价 - 小说由肺动脉高压肺动脉高压术中超声心动图评估的区域SEATP162玻璃血管电容的见解随着少年全身硬化肺源肌腱肌肤，无需保存的射血分数 - 生物标志物在全球纵向菌株的角色在全球纵向菌株P167比分中的一个主动脉根系中的内容：来自二维散斑跟踪Imagep168散热和变形成像的见解，肺高压患者患者患者患者肺动脉高压患者肺动脉高压肺动脉高压术治疗肺动脉高压术治疗的压力载荷和右心室形态和功能通过2D散斑跟踪超声心动图和与常规舒张性参数的关系分析慢性主动脉率高，而不是天然T1的时间，在3TP172LEFT心房菌株中区分扩张或肥厚性心肌病的扩散纤维化在动脉高压症中显着降低了，在动脉高压症P1173例，严重二次二尖瓣重新改善：LV EndDiaal直径（LVEDD）作为休息左侧束分支块中孤立的左束分支块的风险分层P11744444444444444445的概念：探讨了2D对比超声心动图176Chronic心包炎的心肌瘢痕的导电心肌病概念 - 表达罕见具有二维散斑跟踪超声心动图的力学来估算组织多普勒成像的高血压患者左心室重塑：常规人的比较通过半自动方法测量肺血管肺患者肺血管肺水分分布，由肺超声波180surrogalsp181LA变形和LV纵向应变通过二维散斑跟踪超声心动图作为术后AF的预测因子在ASP182LEFT中更换主动脉瓣膜置换后2型糖尿病患者的心室舒张功能障碍非酒精性脂肪肝病患者P183微囊菌株通过斑点跟踪和评估3D乳腺癌中的3D射血分数的评估

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