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首页> 外文期刊>Journal of assisted reproduction and genetics >Assessment of ovarian reserve following ovarian tissue banking and/or GnRH-a co-treatment prior to chemotherapy in patients with Hodgkin's disease.
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Assessment of ovarian reserve following ovarian tissue banking and/or GnRH-a co-treatment prior to chemotherapy in patients with Hodgkin's disease.

机译：霍奇金病患者化疗前卵巢组织库和/或GnRH-a联合治疗后卵巢储备的评估。

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PURPOSE: To examine ovarian reserve following chemotherapy in women with Hodgkin's disease. METHODS: The study included nine patients who underwent ovarian tissue cryopreservation (OTCP) prior to chemotherapy consisting of the ABVD regimen (Adriamycin, bleomycin, vinblastine, and dacarbazine) and co-treatment with gonadotropin-releasing hormone agonist (GnRH-a) (Group A), and 13 patients treated by the ABVD protocol only without GnRH-a (Group B). The average age was 25.2 +/- 2.7 years for the women in Group A and 31.8 +/- 6.8 years for those in Group B. RESULTS: Six months following the end of chemotherapy, the menstrual cycle resumed in all Group A patients and in four Group B patients who had amenorrhea. Eight Group B patients had regular menses during and after chemotherapy. None of the patients suffered from ovarian failure. Two Group A patients conceived in the first year after completing chemotherapy. CONCLUSIONS: Co-treatment with GnRH-a has little effect on ovarian protection in women with Hodgkin's disease.
机译：目的：检查霍奇金氏病女性化疗后的卵巢储备。方法：该研究包括9名在化疗前接受卵巢组织冷冻保存（OTCP）的患者，包括ABVD方案（阿霉素，博来霉素，长春碱和达卡巴嗪）并与促性腺激素释放激素激动剂（GnRH-a）共同治疗（组） A），仅使用GnRH-a的ABVD方案治疗的13例患者（B组）。 A组妇女的平均年龄为25.2 +/- 2.7岁，B组妇女的平均年龄为31.8 +/- 6.8岁。结果：化疗结束后六个月，所有A组患者和接受治疗的女性都恢复了月经周期。 B组4例闭经。 B组8例患者在化疗期间和化疗后有规律的月经。没有患者患有卵巢衰竭。完成化疗后的第一年，有两名A组患者受孕。结论：与GnRH-a共同治疗对霍奇金病女性的卵巢保护作用很小。

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