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首页> 外文期刊>Journal of Alloys and Compounds: An Interdisciplinary Journal of Materials Science and Solid-state Chemistry and Physics >Kupffer cell blockade prevents rejection of human insulinoma cell xenograft in rats
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Kupffer cell blockade prevents rejection of human insulinoma cell xenograft in rats

机译：枯否细胞阻断剂可防止人胰岛素瘤细胞异种移植排斥

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摘要

Alloantigens are recognized by T-cells in the context of both class I and class II antigen, but class II antigens predominate in the recognition of xenoantigens. Since class II molecules bind peptides derived from exogenous proteins that have been phagocytized and digested into small fragments by antigen presenting cells, in the present studies the effect of gadolinium chloride (GdCl3)-induced Kupffer cell blockade on the survival of discordant insulinoma cell xenografts was investigated. Insulinoma cells isolated by means of collagenase from human insulinoma and cultured were transplanted through the v. portae into the liver of streptozotocin-induced diabetic, male, CFY inbred rats. In the control, streptozotocin-treated rats, the decrease in blood glucose level was only transitory, in contrast with the GdCl3-pretreated diabetic rats, which remained normoglycaemic during the 2-week observation period. Histologically, in the liver and lung of rats pre-treated with GdCl3, large areas of extensively proliferating insulinoma cells were seen, whereas no insulinoma cells were seen in either the liver or the lung of diabetic-control rats, not-treated with GdCl3. These studies suggest that the Kupffer cells play significant roles in the recognition of xenoantigens and the induction of xenograft rejection. (C) 1998 Published by Elsevier Science S.A. [References: 8]
机译：在I类和II类抗原的情况下，同种抗原均被T细胞识别，但是II类抗原在异种抗原的识别中占主导地位。由于II类分子结合了已被抗原提呈细胞吞噬并消化成小片段的外源蛋白衍生肽，因此在本研究中，氯化chloride（GdCl3）诱导的Kupffer细胞阻滞对不一致胰岛素瘤细胞异种移植物存活的影响是调查。用胶原酶从人胰岛素瘤中分离并培养的胰岛素瘤细胞通过门静脉移植到链脲佐菌素诱导的糖尿病雄性CFY近交大鼠的肝脏中。在对照中，用链脲佐菌素治疗的大鼠中，血糖水平的降低只是短暂的，与GdCl3预处理的糖尿病大鼠相反，后者在2周的观察期内保持正常血糖水平。从组织学上看，在用GdCl3预处理的大鼠的肝脏和肺中，观察到大面积的广泛增殖的胰岛素瘤细胞，而未用GdCl3处理的糖尿病对照大鼠的肝脏或肺部均未见胰岛素瘤细胞。这些研究表明，枯否细胞在识别异种抗原和诱导异种移植排斥中起重要作用。 （C）1998由Elsevier Science S.A.出版[参考文献：8]

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