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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Analysis of the factors contributing to serum retinol binding protein and transthyretin levels in Japanese adults.
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Analysis of the factors contributing to serum retinol binding protein and transthyretin levels in Japanese adults.

机译：日本成年人血清视黄醇结合蛋白和甲状腺素水平的影响因素分析。

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OBJECTIVE: We examined various factors possibly related to metabolic syndrome, particularly focusing on nutritional assessment proteins such as retinol binding protein (RBP) and transthyretin (TTR), and remnant lipoproteins. MATERIALS AND METHODS: Fasting serum lipid was analyzed in 58 Japanese adult volunteers (33 men and 25 women, 42.5 +/- 10.1 years old). RESULTS: The lipid profiles of the subjects were classified by lipoprotein polyacrylamide gel electrophoretic patterns into Types S (n = 10), A (n = 37), and N (n = 11), according to the method described in Internal Medicine 42: 244, 2003. RBP and TTR were significantly higher in Type N than in Types S and A. In multivariate analysis, RBP was accounted for by remnant-like particle-triglyceride (RLP-TG), interleukin 6, body mass index and low-density lipoprotein (LDL)-cholesterol (adjusted R2 = 0.621). TTR was accounted for by lipoprotein(a), adiponectin and RLP-TG (adjusted R2 = 0.415). Malondialdehyde-LDL was significantly accounted for by LDL-cholesterol and RLP-cholesterol (adjusted R2 = 0.601). Lipoprotein(a) and LDL-cholesterol were independent variables for oxidized LDL antigen (adjusted R2 = 0.620). High-sensitivity C-reactive protein was accounted for by interleukin 6, immunoreactive insulin and oxidized LDL antigen (adjusted R2 = 0.361). Uric acid and body mass index were independent variables for adiponectin (adjusted R2 = 0.429).Conclusion: RBP and TTR may be useful as convenient and simple clinical markers of overnutrition and possibly of metabolic syndrome.
机译：目的：我们研究了可能与代谢综合征有关的各种因素，特别是着重于营养评估蛋白，例如视黄醇结合蛋白（RBP）和运甲状腺素蛋白（TTR），以及残留的脂蛋白。材料与方法：对58名日本成人志愿者（33名男性和25名女性，42.5 +/- 10.1岁）进行了空腹血脂分析。结果：根据《内科医学》第42期中所述的方法，通过脂蛋白聚丙烯酰胺凝胶电泳模式将受试者的脂质概况分为S型（n = 10），A（n = 37）和N（n = 11）： 244，2003年。N型的RBP和TTR明显高于S型和A型。在多变量分析中，RBP是由残留样甘油三酸酯（RLP-TG），白介素6，体重指数和低血脂引起的。密度脂蛋白（LDL）-胆固醇（调整后的R2 = 0.621）。 TTR由脂蛋白（a），脂联素和RLP-TG引起（调整后的R2 = 0.415）。丙二醛-LDL是LDL-胆固醇和RLP-胆固醇的重要组成部分（调整后的R2 = 0.601）。脂蛋白（a）和LDL-胆固醇是氧化的LDL抗原的独立变量（调整后的R2 = 0.620）。高敏感性C反应蛋白是由白介素6，免疫反应性胰岛素和氧化的LDL抗原引起的（调整后的R2 = 0.361）。尿酸和体重指数是脂联素的独立变量（调整后的R2 = 0.429）。结论：RBP和TTR可能是营养过剩和代谢综合征的便捷简便的临床指标。

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