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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Thr-encoding allele homozygosity at codon 54 of FABP 2 gene may be associated with impaired delta 6 desatruase activity and reduced plasma arachidonic acid in obese children.
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Thr-encoding allele homozygosity at codon 54 of FABP 2 gene may be associated with impaired delta 6 desatruase activity and reduced plasma arachidonic acid in obese children.

机译：肥胖儿童中FABP 2基因第54位密码子的Thr编码等位基因纯合性可能与delta 6脱氢酶活性受损和血浆花生四烯酸降低有关。

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BACKGROUND: Alanine-for-threonine substitution at codon 54 (A54T polymorphism) in the fatty acid-binding protein 2 gene (FABP2) has been associated with hypertriglyceridemia and insulin resistance. Impairment in the activity of delta 6 and 5 desaturases is also supposed to be a factor predisposing the development of insulin resistance syndrome. AIM: We investigated the relationship between A54T polymorphism in FABP2 and the impairment of long-chain polyunsaturated fatty acid metabolism in obese children. METHODS: Thirty-two obese children participated. During the study, the children continued their habitual diet, which was documented in a 3-day food record using household measures. Anthropometry was performed, and serum lipid and fatty acid composition in plasma were analyzed. The polymorphism of codon 54 in the FABP 2 gene was analyzed. RESULTS: The allele frequency was 0.66 and 0.34 for Ala54 and Thr54, respectively. There were no significant differences in age, body mass index, fasting serum glucose, insulin or serum lipoproteins among the three polymorphism groups. These were also no significant differences in the intake of energy, the percentage of energy nutrients or in the dietary lipid composition. The content of arachidonic acid (AA) in plasma was lowest in Thr/Thr54 (p < 0.05). The indices of delta-6 desaturase (D6D) activity in Thr/Thr54 were significantly lower than in Thr/Ala54 or Ala/Ala54 (p < 0.05, p < 0.01, respectively). CONCLUSIONS: In obese children, Thr/Thr54 of the FABP 2 gene is associated with impaired activation of D6D and reduced AA content. The results in the LCPUFA profile suggest that Thr/Thr54 may predispose the to development of insulin resistance.
机译：背景：脂肪酸结合蛋白2基因（FABP2）中第54位密码子（A54T多态性）的苏氨酸取代苏氨酸与高甘油三酯血症和胰岛素抵抗有关。 Δ6和5去饱和酶活性的减弱也被认为是诱发胰岛素抵抗综合征发展的因素。目的：我们研究了肥胖儿童中FABP2的A54T多态性与长链多不饱和脂肪酸代谢受损之间的关系。方法：32名肥胖儿童参加。在研究过程中，孩子们继续习惯饮食，这是通过家庭措施记录在3天的饮食记录中的。进行人体测量，并分析血浆中的血脂和脂肪酸组成。分析了FABP 2基因中密码子54的多态性。结果：Ala54和Thr54的等位基因频率分别为0.66和0.34。三个多态性组之间的年龄，体重指数，空腹血糖，胰岛素或血清脂蛋白无显着差异。这些在能量摄入，能量营养成分百分比或饮食脂质组成方面也无显着差异。血浆中花生四烯酸（AA）的含量在Thr / Thr54中最低（p <0.05）。 Thr / Thr54中的delta-6去饱和酶（D6D）活性指数显着低于Thr / Ala54或Ala / Ala54中（分别为p <0.05，p <0.01）。结论：在肥胖儿童中，FABP 2基因的Thr / Thr54与D6D激活受损和AA含量降低有关。 LCPUFA谱中的结果表明，Thr / Thr54可能促进胰岛素抵抗的发展。

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