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首页> 外文期刊>Journal of autism and developmental disorders >Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep
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Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep

机译：自闭症谱系障碍儿童的褪黑激素：与睡眠有关的内源性和药代动力学特征。

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摘要

Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C_(max)) and time to peak concentration (Tmax) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin.
机译：补充褪黑激素已用于治疗自闭症谱系障碍（ASD）儿童的睡眠发作性失眠，尽管其作用机理尚不确定。我们评估了与9名ASD儿童的睡眠有关的内源性和补充性褪黑激素概况。在内源性样本中，最大褪黑激素浓度（C_（max））和达到峰值浓度的时间（Tmax）与以前发表于典型发育中儿童的文献相当，并且大多数儿童中都发现了昏暗的褪黑素发作。在治疗样本（补充褪黑激素）中，褪黑激素参数也与以前针对典型发育儿童发布的参数相当。我们的研究结果支持对低剂量褪黑激素治疗有反应的ASD和失眠儿童具有相对正常的内源性和补充性褪黑激素特征。

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