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首页> 外文期刊>Journal of Basic Microbiology: An International Journal on Morphology, Physiology, Genetics, and Ecology of Microorganisms >Outer membrane proteins of Fusobacterium necrophorum subsp. necrophorum and subsp. funduliforme
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Outer membrane proteins of Fusobacterium necrophorum subsp. necrophorum and subsp. funduliforme

机译：坏死镰刀菌亚种的外膜蛋白。死灵菌和亚种。 uli形目

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摘要

Fusobacterium necrophorum, classified into subsp. necrophorum (Fnn) and subsp. funduliforme (Fnf), is frequently associated with necrotic infections of animals and humans. The outer membrane proteins (OMP) of many Gram negative bacteria play an important role in bacterial adhesion and establishment of infection. The OMP profile of F. necrophorum has not been well characterized. We analyzed OMP of bovine strains of Fnn and Fnf and human strains of F. necrophorum. Electrophoretic separations of extracted OMP of Fnn and Fnf strains of cattle showed a total of 19 and 20 protein bands, respectively. The most prominent protein band was 40kDa in Fnn and 37.5kDa in Fnf. The four human clinical strains examined had more heterogeneous banding patterns and had different profiles than those of bovine Fnf strains. A total of 11 protein bands in Fnn and 13 protein bands in Fnf were recognized by sera from cattle with liver abscesses. The intensities of many of the bands in Fnn were higher than that of Fnf. We conclude that the two subspecies of F. necrophorum differ in their OMP profiles and the difference may account for differences in their virulence and involvement in the pathogenesis of necrotic infections.
机译：坏死镰刀菌，分为亚种。死灵菌（Fnn）和亚种。眼底（Fnf）通常与动物和人类的坏死感染有关。许多革兰氏阴性细菌的外膜蛋白（OMP）在细菌粘附和感染的建立中起着重要作用。坏死镰刀菌的OMP图谱尚未很好地表征。我们分析了牛Fnn和Fnf菌株和人类F. necrophorum菌株的OMP。牛Fnn和Fnf菌株提取的OMP的电泳分离分别显示了19条和20条蛋白带。最突出的蛋白条带在Fnn中为40kDa，在Fnf中为37.5kDa。与牛Fnf菌株相比，所检查的四种人类临床菌株具有更多的异质结合模式，并且具有不同的谱。患有肝脓肿的牛的血清中共识别出Fnn中的11条蛋白带和Fnf中的13条蛋白带。 Fnn中许多带的强度都高于Fnf。我们得出的结论是，坏死镰刀菌的两个亚种在OMP谱上有所不同，并且该差异可能解释了它们的毒力和坏死感染发病机理的差异。

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