SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.

Pissarnitski DA; Asberom T; Boyle CD; Chackalamannil S; Chintala M; Clader JW; Greenlee WJ; Hu Y; Kurowski S; Myers J; Palamanda J; Stamford AW; Vemulapalli S; Wang Y; Wang P; Wu P; Xu R

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.

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SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.

机译：SAR开发多环鸟嘌呤衍生物的目的是发现选择性PDE5抑制剂以治疗勃起功能障碍。

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Development of structure-activity relationship of cyclic guanines I lead us to discovery of a potent and selective series of phosphodiesterase 5 inhibitors 52-59 (IC50=1.3-11.0 nM, PDE6/5=116-600).

机译：环状鸟嘌呤的构效关系的发展我引导我们发现了一种有效而选择性的磷酸二酯酶5抑制剂系列52-59（IC50 = 1.3-11.0 nM，PDE6 / 5 = 116-600）。

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《Bioorganic and Medicinal Chemistry Letters》 |2004年第5期|共4页
作者
Pissarnitski DA; Asberom T; Boyle CD; Chackalamannil S; Chintala M; Clader JW; Greenlee WJ; Hu Y; Kurowski S; Myers J; Palamanda J; Stamford AW; Vemulapalli S; Wang Y; Wang P; Wu P; Xu R;
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正文语种 eng
中图分类基础医学;
关键词
development aspects; derivatives; Erectile Dysfunction; therapeutic aspects; 鸟嘌呤;

机译：发展方面;衍生物;勃起功能障碍;治疗方面;鸟嘌呤;

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专利

1. 意大利临床实践中的PDE5抑制剂治疗模式：“勃起功能障碍观测研究”的纵向数据 [J] . Ferdinando Fusco意大利, Riccardo Sicuteri意大利, Andrea Rossi意大利, 亚洲男性学杂志：英文版 . 2009,第005期
2. SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction. [J] . Pissarnitski DA, Asberom T, Boyle CD, Bioorganic and Medicinal Chemistry Letters . 2004,第5期

机译：SAR开发多环鸟嘌呤衍生物的目的是发现选择性PDE5抑制剂以治疗勃起功能障碍。
3. Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction. [J] . Bi Y, Stoy P, Adam L, Bioorganic and Medicinal Chemistry Letters . 2004,第6期

机译：喹啉作为强效和选择性PDE5抑制剂，可作为治疗勃起功能障碍的潜在药物。
4. Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction. [J] . Jiang W, Sui Z, Macielag MJ, Journal of Medicinal Chemistry . 2003,第3期

机译：呋喃基和苯并呋喃基吡咯并喹诺酮类药物作为有效和选择性的PDE5抑制剂，可治疗勃起功能障碍。
5. Adenine and guanine derivative bases of purines and their corresponding nucleosides as corrosion inhibitors in 1M hydrochloric acid [C] . D.Y. Cruz Gonzalez, G. Negron Silva, D. Angeles Beltran, MES 26: Electrochemistry as a tool for sustainable development . 2011

机译：嘌呤的腺嘌呤和鸟嘌呤衍生物碱基及其相应的核苷在1M盐酸中的腐蚀抑制剂
6. New approaches for treatment of erectile dysfunction in conditions of low nitric oxide formation or bioavailability: Investigation of rho-kinase inhibitors and soluble guanylate cyclase-targeted therapies. [D] . Lasker, George Franklin. 2016

机译：在低一氧化氮形成或生物利用度条件下治疗勃起功能障碍的新方法：研究rho激酶抑制剂和可溶性鸟苷酸环化酶靶向疗法。
7. Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development [O] . Gülru Kayık, Nurcan Ş. Tüzün, Serdar Durdagi 2017

机译：使用分子建模方法基于分子指纹的虚拟筛选方案和基于结构的药效团开发相结合的研究PDE5 / PDE6和PDE5 / PDE11选择性强效他达拉非类PDE5抑制剂
8. Targeting the SARS-CoV-2 3CLpro and NO/cGMP/PDE5 pathway in COVID-19: a commentary on PDE5 inhibitors [O] . Milad Shirvaliloo 2021

机译：在Covid-19中靶向SARS-COV-2 3 CLPRO和NO / CGMP / PDE5途径：PDE5抑制剂的评论

SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.

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