Bioinspired and biomimetic systems-Functional ribonucleotide reductase enzyme models

Miklós István Szávuly; József Kaizer; Gábor Speier

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Bioinspired and biomimetic systems-Functional ribonucleotide reductase enzyme models

机译：生物启发和仿生系统功能核糖核苷酸还原酶模型

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Dioxygen activation by non-hem diiron enzymes occurs in a number of metabolically important transformations including the conversion of ribonucleotides to deoxyribonucleotides by ribonucleotide reductase (RNR) [1], the formation of unsaturated fatty acids by fatty acid desaturases, the biosynthesis of antibiotics (CmlA, CmlI). In general, O_2 activation is thought to be initiated by the binding of O_2 to the diiron(II) center to form a peroxidodiiron(III) intermediate that in turn converts to the oxidizing species. Peroxidodiiron(III) intermediates with visible features between 600–750 nm have been identified for RNR R2 [2].

机译：非下摆二铁酶的双氧激活发生在许多代谢上重要的转变中，包括核糖核苷酸还原酶（RNR）将核糖核苷酸转化为脱氧核糖核苷酸[1]，脂肪酸去饱和酶形成不饱和脂肪酸，抗生素的生物合成（CmlA ，CmlI）。通常，O_2活化被认为是由O_2与二铁（II）中心结合形成过氧化物二铁（III）中间体而引发的，而该中间体又转化为氧化物质。 RNR R2已鉴定出可见特征在600-750 nm之间的过氧化物二铁（III）中间体[2]。

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《Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry》 |2014年第null期|共1页
作者
Miklós István Szávuly; József Kaizer; Gábor Speier;
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正文语种 eng
中图分类生物化学;
关键词
peroxidodiiron; Peroxidodiiron; identified;

机译：过氧化物二铁;过氧化物二铁;鉴定;

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1. Bioinspired and biomimetic systems-Functional ribonucleotide reductase enzyme models [J] . Miklós István Szávuly, József Kaizer, Gábor Speier Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2014,第Null期

机译：生物启发和仿生系统功能核糖核苷酸还原酶模型
2. Biomimetic Modeling of the Decomposition of 2'-Chloro-2'-deoxynucleotides by Ribonucleotide Reductases To Give 3(2H)-Furanones Which Can Effect Mechanism-Based Inactivation by Michael-Type Alkylation [J] . Morris J. Robins, Zhiqiang Guo, Mima C. Samano, Journal of the American Chemical Society . 1996,第45期

机译：核糖核苷酸还原酶分解2'-Chloro-2'-脱氧核苷酸的仿生模型，得到3（2H）-呋喃酮，可以影响基于Michael型烷基化的机制失活
3. Ribonucleotide activation by enzyme ribonucleotide reductase: Understanding the role of the enzyme [J] . Cerqueira NMFSA, Fernandes PA, Eriksson LA, Journal of Computational Chemistry: Organic, Inorganic, Physical, Biological . 2004,第16期

机译：核糖核苷酸还原酶激活核糖核苷酸：了解该酶的作用
4. A comprehensive model for the allosteric regulation of Class la ribonucleotide reductases [C] . Barry S. Cooperman, Ossama B. Kashlan International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：La Ribon核苷酸还原酶的变构调节综合模型
5. Biomimetic modeling of the nitrogen-centered radical postulated to occur during the inhibition of ribonucleotide reductases by 2'-azido-2'-deoxynucleotides [D] . Dang, Thao P. 2010

机译：拟定在2'-叠氮基2'-脱氧核苷酸抑制核糖核苷酸还原酶过程中发生的氮中心自由基的仿生模拟
6. Dehydration of Ribonucleotides Catalyzed by Ribonucleotide Reductase: The Role of the Enzyme [O] . Nuno M. F. S. A. Cerqueira, Pedro Alexandrino Fernandes, Leif A. Eriksson, 2006

机译：核糖还原酶催化的核糖脱水：酶的作用。
7. Biomimetic Modeling of the Nitrogen-centered Radical Postulated to occur during the Inhibition of Ribonucleotide Reductases by 2u27-Azido-2u27-deoxynucleotides. [O] . Dang Thao P. 2010

机译：假定在通过2'-27-叠氮基-2脱氧核苷酸抑制核糖核苷酸还原酶期间发生的氮中心自由基的仿生建模。

Bioinspired and biomimetic systems-Functional ribonucleotide reductase enzyme models

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