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首页> 外文期刊>Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry >Metal–nucleic acid interactions-Purification and isolation of platinated RNA
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Metal–nucleic acid interactions-Purification and isolation of platinated RNA

机译：金属与核酸的相互作用-镀铂RNA的纯化和分离

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摘要

Nucleic acids are an important potential drug target and we are currently investigating the way in which platinum anticancer drugs interact with RNA. These drugs are normally thought to exert their activity upon covalent binding to DNA purine nitrogens [1]. However in recent years potential alternative binding partners have been explored, including RNA [2]. The latter has many important functions in vivo and the disruption of these processes can have serious consequences [3]. It has already been reported that some RNA dependent activities are inhibited upon administration of platinum drugs, but still little is known on the effects of platinum drugs on RNA structure and biology [2–4].
机译：核酸是重要的潜在药物靶标，我们目前正在研究铂类抗癌药物与RNA相互作用的方式。通常认为这些药物在与DNA嘌呤氮共价结合时发挥其活性[1]。然而，近年来，已经探索了潜在的替代结合伴侣，包括RNA [2]。后者在体内具有许多重要功能，破坏这些过程可能会产生严重后果[3]。已有报道称，服用铂类药物会抑制某些RNA依赖的活性，但对于铂类药物对RNA结构和生物学的影响知之甚少[2-4]。

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