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首页> 外文期刊>Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry >Metals in medicine: metal-related diseases-Synthesis, characterization and anticancer activity of (thio)pyrone-derived organometallic complexes
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Metals in medicine: metal-related diseases-Synthesis, characterization and anticancer activity of (thio)pyrone-derived organometallic complexes

机译：医药中的金属：与金属有关的疾病-（硫代）吡喃酮衍生的有机金属配合物的合成，表征和抗癌活性

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摘要

Non-platinum tumor-inhibiting metal and organometallic complexes have gained increasing interest in recent years. One promising approach is the coordination of organometallic fragments to bioactive molecules. Pyrones are known for their bioavailability, favorable toxicity profile and high affinity towards metal ions. This intensively studied ligand system can be easily converted to the respective thiopyrone which offer a potential S,O coordination motif. It has already been shown that thiopyrone-based Ru(II) complexes provide an increased stability under physiological conditions and a different biomolecule interaction profile compared to the pyrone analogues. In addition, these organometallics exhibit promising cytotoxicity in vitro [1,2] and are currently investigated in vivo.
机译：近年来，非铂抑制肿瘤的金属和有机金属络合物越来越受到关注。一种有前途的方法是有机金属片段与生物活性分子的配位。吡喃酮以其生物利用度，良好的毒性和对金属离子的高亲和力而闻名。经过深入研究的配体体系可以轻松转化为具有潜在S，O配位基序的相应噻喃酮。已经显示，与吡喃酮类似物相比，基于硫吡喃酮的Ru（II）配合物在生理条件下具有增强的稳定性，并具有不同的生物分子相互作用。此外，这些有机金属在体外表现出有希望的细胞毒性[1,2]，目前正在体内进行研究。

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