...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of asthma >Association between angiotensin-converting enzyme I/D polymorphism and asthma risk: A meta-analysis involving 11,897 subjects
【24h】

Association between angiotensin-converting enzyme I/D polymorphism and asthma risk: A meta-analysis involving 11,897 subjects

机译：血管紧张素转换酶I / D多态性与哮喘风险之间的关联：一项涉及11,897名受试者的荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Genetic susceptibility to asthma has been a research focus in the scientific community. Several studies have been conducted in recent years to evaluate the risk of asthma and insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE). However, the results remain conflicting rather than conclusive. Methods. We carried out a search in Medline, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) database for relevant studies. Data were extracted using a standardized form and pooled odds ratios (ORs) with 95 confidence intervals (CIs) were calculated to assess the strength of the association. Results. Our meta-analysis on 11,897 subjects from all available studies showed that the DD genotype was associated with increased asthma risk than those with the II (OR = 1.59, 95% CI = 1.20-2.12) or ID/II (OR = 1.62, 95% CI = 1.24-2.10) genotype. Stratified analyses by ethnicity (Europeans and Asians) and age (adults and children) obtained statistically similar results in the two genetic models. In the subgroup analysis by source of controls, the DD genotype was associated with a significantly elevated risk of asthma among population-based controls (DD vs. II: OR = 2.27, 95% CI = 1.45-3.56) but not hospital-based controls (DD vs. II: OR = 1.18, 95% CI = 0.93-1.49). Conclusions. This meta-analysis provides strong evidence that the I/D polymorphism of ACE is associated with asthma risk. Additional well-designed large studies were required for the validation of our results, especially in African populations.
机译：背景。哮喘的遗传易感性一直是科学界的研究重点。近年来进行了数项研究，以评估哮喘风险和血管紧张素转换酶（ACE）的插入/缺失（I / D）多态性。但是，结果仍然是矛盾的，而不是结论性的。方法。我们在Medline，EMBASE和中国国家知识基础设施（CNKI）数据库中进行了搜索，以进行相关研究。使用标准化形式提取数据，并计算具有95个置信区间（CI）的合并比值比（OR），以评估关联的强度。结果。我们对来自所有可用研究的11897名受试者的荟萃分析表明，与II型（OR = 1.59，95％CI = 1.20-2.12）或ID / II（OR = 1.62，95）相比，DD基因型与哮喘风险增加相关。 ％CI = 1.24-2.10）基因型。在两个遗传模型中，按种族（欧洲人和亚洲人）和年龄（成人和儿童）进行的分层分析获得了统计上相似的结果。在按对照来源进行的亚组分析中，DD基因型与以人群为基础的对照中哮喘风险显着升高相关（DD vs. II：OR = 2.27，95％CI = 1.45-3.56），而非以医院为基础的对照（DD vs.II：OR = 1.18，95％CI = 0.93-1.49）。结论。这项荟萃分析提供了有力的证据，证明ACE的I / D多态性与哮喘风险有关。为了验证我们的结果，还需要进行其他精心设计的大型研究，尤其是在非洲人群中。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号