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Modeling and analysis of biopathways dynamics

机译:生物途径动力学的建模和分析

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摘要

Cellular processes are governed and coordinated by a multitude of biopathways. A pathway can be viewed as a complex network of biochemical reactions. The dynamics of this network largely determines the functioning of the pathway. Hence the modeling and analysis of biochemical networks dynamics is an important problem and is an active area of research. Here we review quantitative models of biochemical networks based on ordinary differential equations (ODEs). We mainly focus on the parameter estimation and sensitivity analysis problems and survey the current methods for tackling them. In this context we also highlight a recently developed probabilistic approximation technique using which these two problems can be considerably simplified.
机译:细胞过程受多种生物途径控制和协调。途径可以看作是生化反应的复杂网络。该网络的动力学在很大程度上决定了通路的功能。因此,生化网络动力学的建模和分析是一个重要的问题,并且是一个活跃的研究领域。在这里,我们回顾基于常微分方程(ODE)的生化网络的定量模型。我们主要关注参数估计和灵敏度分析问题,并调查解决这些问题的当前方法。在这种情况下,我们还重点介绍了最近开发的概率近似技术,使用该技术可以大大简化这两个问题。

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