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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >REPERTOIRE OF PROTEIN KINASES ENCODED IN THE GENOME OF ZEBRAFISH SHOWS REMARKABLY LARGE POPULATION OF PIM KINASES
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REPERTOIRE OF PROTEIN KINASES ENCODED IN THE GENOME OF ZEBRAFISH SHOWS REMARKABLY LARGE POPULATION OF PIM KINASES

机译：斑马鱼显示基因组中编码的蛋白激酶库，大量的PIM激酶种群

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In recent times, zebrafish has garnered lot of popularity as model organism to study human cancers. Despite high evolutionary divergence from humans, zebrafish develops almost all types of human tumors when induced. However, mechanistic details of tumor formation have remained largely unknown. Present study is aimed at analysis of repertoire of kinases in zebrafish proteome to provide insights into various cellular components. Annotation using highly sensitive remote homology detection methods revealed "substantial expansion" of Ser/Thr/Tyr kinase family in zebrafish compared to humans, constituting over 3% of proteome. Subsequent classification of kinases into subfamilies revealed presence of large number of CAMK group of kinases, with massive representation of PIM kinases, important for cell cycle regulation and growth. Extensive sequence comparison between human and zebrafish PIM kinases revealed high conservation of functionally important residues with a few organism specific variations. There are about 300 PIM kinases in zebrafish kinome, while human genome codes for only about 500 kinases altogether. PIM kinases have been implicated in various human cancers and are currently being targeted to explore their therapeutic potentials. Hence, in depth analysis of PIM kinases in zebrafish has opened up new avenues of research to verify the model organism status of zebrafish.
机译：近年来，作为研究人类癌症的模型生物，斑马鱼已广受欢迎。尽管与人类的进化差异很大，但斑马鱼在被诱导时会发展出几乎所有类型的人类肿瘤。然而，肿瘤形成的机制细节仍然很大程度上未知。本研究旨在分析斑马鱼蛋白质组中激酶的组成部分，以提供对各种细胞成分的认识。使用高度灵敏的远程同源性检测方法进行的注释显示，与人类相比，斑马鱼中Ser / Thr / Tyr激酶家族“显着扩展”，占蛋白质组的3％以上。随后将激酶分类为亚家族，表明存在大量的CAMK组激酶，大量代表PIM激酶，对细胞周期调节和生长很重要。人类和斑马鱼PIM激酶之间的广泛序列比较表明，具有重要功能的残基具有高度的保守性，且具有一些特定于生物体的变异。斑马鱼的基因组中大约有300种PIM激酶，而人类基因组总共只编码大约500种激酶。 PIM激酶已经牵涉到各种人类癌症中，并且目前正被用于探索其治疗潜力。因此，对斑马鱼中PIM激酶的深入分析开辟了新的研究途径，以验证斑马鱼的模型生物状态。

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