MATHEMATICAL MODELING OF LIVING CELL METABOLISM USING THE METHOD OF STEADY-STATE STOICHIOMETRIC FLUX BALANCE

L. N. DROZDOV-TIKHOMIROV; G. I. SCURIDA; A. V. DAVIDOV; A. A. ALEXANDROV; R. A. ZVYAGILSKAYA

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MATHEMATICAL MODELING OF LIVING CELL METABOLISM USING THE METHOD OF STEADY-STATE STOICHIOMETRIC FLUX BALANCE

机译：稳态化学计量通量平衡法在活细胞代谢的数学模型中的应用

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This approach uses a set of algebraic linear equations for reaction rates (the method of steady-state stoichiometric flux balance) to model the purposeful metabolism of the living self-reproducing biochemical system (i.e. cell), which persists in steady-state growth. Linear programming (SIMPLEX method) is used to derive the solution for the model equations set (determining reaction rates which provide flux balance at given conditions). Here, we demonstrate the approach through the mathematical modeling of steady-state metabolism in Saccharomyces cerevisiae mitochondria.

机译：该方法使用一组代数线性方程式来表示反应速率（稳态化学计量通量平衡的方法），以模拟存活的自我繁殖生化系统（即细胞）的有目的代谢，该代谢过程持续稳定生长。线性编程（SIMPLEX方法）用于得出模型方程组的解（确定在给定条件下可提供通量平衡的反应速率）。在这里，我们通过酿酒酵母线粒体稳态代谢的数学建模演示了该方法。

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来源
《Journal of Bioinformatics and Computational Biology》 |2006年第4期|共21页
作者
L. N. DROZDOV-TIKHOMIROV; G. I. SCURIDA; A. V. DAVIDOV; A. A. ALEXANDROV; R. A. ZVYAGILSKAYA;
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正文语种 eng
中图分类细胞生物学;
关键词
Steady-state stoichiometric flows balance; mathematical modeling; self-reproducing biochemical system; Saccharomyces cerevisiae; mitochondria;

机译：稳态化学计量流量平衡;数学模型;自生生化系统;酿酒酵母;线粒体;

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1. MATHEMATICAL MODELING OF LIVING CELL METABOLISM USING THE METHOD OF STEADY-STATE STOICHIOMETRIC FLUX BALANCE [J] . L. N. DROZDOV-TIKHOMIROV, G. I. SCURIDA, A. V. DAVIDOV, Journal of Bioinformatics and Computational Biology . 2006,第4期

机译：稳态化学计量通量平衡法在活细胞代谢的数学模型中的应用
2. Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints. [J] . Ramakrishna R, Edwards JS, McCulloch A, American Journal of Physiology . 2001,第3期

机译：线粒体能量代谢的通量平衡分析：系统化学计量约束的后果。
3. Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. [J] . A Varma, B O Palsson Applied and Environmental Microbiology . 1994,第10期

机译：化学计量通量平衡模型定量预测野生型大肠杆菌W3110中的生长和代谢副产物分泌。
4. Flux Balance Analysis: An Insilico Analysis of Staphylococcus aureus Cell Wall Biosynthesis Pathway Metabolism [C] . Johari Surabhi, Dey Priyanka, Sharma Ashwani, 2013 International Conference on Machine Intelligence Research and Advancement . 2013

机译：助焊剂平衡分析：金黄色葡萄球菌细胞壁生物合成途径代谢的硅化学分析
5. Development of Steady-State and Dynamic Flux Models for Broad-Scope Microbial Metabolism Analysis. [D] . He, Lian. 2016

机译：开发用于稳态微生物代谢分析的稳态和动态通量模型。
6. Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. [O] . A Varma, B O Palsson 1994

机译：化学计量通量平衡模型定量预测野生型大肠杆菌W3110中的生长和代谢副产物分泌。
7. Kinetic models of metabolism that consider alternative steady-state solutions of intracellular fluxes and concentrations [O] . Tuure Hameri, Georgios Fengos, Meric Ataman, 2018

机译：代谢的动力学模型考虑细胞内助熔剂和浓度的替代稳态解

MATHEMATICAL MODELING OF LIVING CELL METABOLISM USING THE METHOD OF STEADY-STATE STOICHIOMETRIC FLUX BALANCE

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