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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >Bioinformatic analysis of the neutrality of RNA secondary structure elements across genotypes reveals evidence for direct evolution of genetic robustness in HCV
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Bioinformatic analysis of the neutrality of RNA secondary structure elements across genotypes reveals evidence for direct evolution of genetic robustness in HCV

机译：对跨基因型的RNA二级结构元件的中性进行生物信息学分析，揭示了HCV遗传稳健性直接进化的证据

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The properties and origin of genetic robustness have recently been investigated in several works that examined microRNA stem-loop structures, and a variety of conclusions have been reached without agreement. Considering that this is a universal phenomenon that is not restricted to miRNAs, we recall the original work on this topic that began from looking at viral RNAs of several types. We provide a link to this work by examining the neutrality of HCV structural elements, performing a detailed bioinformatic analysis using RNA secondary structure predictions across genotypes. This study provides supporting evidence for direct evolution of genetic robustness that is not limited to noncoding RNAs participating in gene regulation, but includes functionally important structural elements of the hepatitis C virus (HCV) that show excess of robustness beyond the intrinsic robustness of their stem-loop structure. These findings further support the adaptive behavior of genetic robustness in functional RNAs of various types that seem to have evolved with selection pressure towards increased robustness.
机译：最近，在检查microRNA茎环结构的几项研究中研究了遗传稳健性的性质和起源，并且未经同意就得出了各种结论。考虑到这是一种普遍现象，不仅限于miRNA，因此我们回顾了该主题的原始工作，该工作始于研究几种类型的病毒RNA。我们通过检查HCV结构元件的中立性，使用跨基因型的RNA二级结构预测进行详细的生物信息学分析来提供与这项工作的链接。这项研究为遗传稳健性的直接进化提供了支持性证据，其不仅限于参与基因调控的非编码RNA，还包括丙型肝炎病毒（HCV）的功能上重要的结构元件，显示出超过其茎固有的稳健性的稳健性。循环结构。这些发现进一步支持了遗传稳健性在各种类型的功能性RNA中的适应性行为，这些功能性RNA似乎随着选择压力而向稳健性提高。

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