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首页> 外文期刊>Journal of biochemical and molecular toxicology >Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells
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Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells

机译：白藜芦醇苷诱导细胞凋亡并抑制急性单核细胞白血病细胞的生长。

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摘要

Polydatin (PD), a component isolated from Polygonum cuspidatum, has various activities such as inhibiting platelet aggregation, lowering level of blood lipid, reducing lipid peroxidation, and so on. However, the antitumor activity of PD has been poorly reported. In the present study, effect of PD on cell proliferation was evaluated by Cell Counting Kit-8, and cell cycle and apoptosis were investigated by flow cytometry. Meanwhile, the protein expression level of Bc1-2, Bax, cyclin A, cyclin B, and cyclin D1, which associated with apoptosis and cell cycle were analyzed by Western blotting. Results show that PD could effectively inhibit the growth, arrest cells in S phase, and induce apoptosis of acute monocytic leukemia cell line THP-1; meanwhile, expression of cyclin D1 and Bc1-2 decreased significantly, and expression of Bax and cyclin A increased notably. All results suggest that PD maybe a potential therapeutic strategy for acute monocytic leukemia.
机译：从虎杖中分离出的成分Polydatin（PD）具有多种活性，例如抑制血小板聚集，降低血脂水平，减少脂质过氧化作用等。然而，关于PD的抗肿瘤活性的报道很少。在本研究中，通过Cell Counting Kit-8评估了PD对细胞增殖的影响，并通过流式细胞术研究了细胞周期和凋亡。同时，通过Western印迹分析了Bc1-2，Bax，细胞周期蛋白A，细胞周期蛋白B和细胞周期蛋白D1的蛋白表达水平，其与细胞凋亡和细胞周期相关。结果表明，PD可以有效抑制急性单核细胞白血病细胞THP-1的生长，使其处于S期，并诱导其凋亡。同时，cyclin D1和Bc1-2的表达显着下降，而Bax和cyclin A的表达显着增加。所有结果表明PD可能是急性单核细胞白血病的潜在治疗策略。

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