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首页> 外文期刊>Journal of biochemical and molecular toxicology >Downregulation of Microrna-148a in Cancer-Associated Fibroblasts from Oral Cancer Promotes Cancer Cell Migration and Invasion by Targeting Wnt10b
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Downregulation of Microrna-148a in Cancer-Associated Fibroblasts from Oral Cancer Promotes Cancer Cell Migration and Invasion by Targeting Wnt10b

机译：口腔癌的癌相关成纤维细胞中Microrna-148a的下调通过靶向Wnt10b促进癌细胞的迁移和侵袭

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摘要

It is well established that crosstalk between cancer-associated fibroblasts (CAFs) and cancer cells plays a critical role in the occurrence and development of oral squamous cell carcinoma (OSCC). The molecular mechanisms underlying such interaction, however, remain far from clear. Accumulating data have indicated that microRNAs involved in tumor microenvironment, particularly in CAFs, contribute to the activation of fibroblasts and metastasis of cancer cells. Here, we showed that miR-148a was downregulated in CAFs compared with normal fibroblasts isolated from clinical OSCC tissue. Investigation of miR-148a function in fibroblasts demonstrated that overexpression of miR-148a in CAFs significantly impaired the migration and invasion of oral carcinoma cells (SCC-25) by directly targeting WNT10B. Taken together, these data suggested that miR-148a might be a novel candidate target for the treatment of OSCC.
机译：众所周知，癌症相关的成纤维细胞（CAF）与癌细胞之间的串扰在口腔鳞状细胞癌（OSCC）的发生和发展中起着至关重要的作用。但是，这种相互作用的分子机制还很不清楚。越来越多的数据表明，参与肿瘤微环境（尤其是CAF）的microRNA有助于成纤维细胞的活化和癌细胞的转移。在这里，我们显示与从临床OSCC组织分离的正常成纤维细胞相比，CAFs中的miR-148a被下调。对成纤维细胞中miR-148a功能的研究表明，CAF中miR-148a的过度表达通过直接靶向WNT10B显着削弱了口腔癌细胞（SCC-25）的迁移和侵袭。综上所述，这些数据表明miR-148a可能是OSCC治疗的新型候选靶标。

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