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首页> 外文期刊>Journal of biochemical and molecular toxicology >A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins.
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A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins.

机译：Ah受体在细胞信号传导中的动态作用？来自各种Ah受体相互作用蛋白的见解。

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摘要

The aryl hydrocarbon (Ah) receptor (AhR) is a member of the basic helix-loop-helix PER-ARNT-SIM (PAS) transcription factor family. Consistent with the notion that PAS proteins are biological sensors, AhR binding to Ah toxicants induces or represses transcription of a wide range of genes and results in a cascade of toxic responses. However, an endogenous role for AhR in development and homeostasis is supported by (1) the discovery of low affinity, endogenous ligands; (2) studies demonstrating a role for the receptor in development of liver and vascular systems, that were established using mice lacking AhR expression; and (3) the presence of functional dioxin-responsive elements in promoter regions of genes involved in cellular growth and differentiation. A large body of recent literature has implicated AhR in multiple signal transduction pathways. AhR is known to interact with signaling pathways that are mediated by estrogen receptor and other hormone receptors, hypoxia, nuclear factor kappaB, and retinoblastoma protein. In addition, AhR complexes may affect cellular signaling through interactions with various other regulatory and signaling proteins, including PAS heterodimerization partners (ARNT), chaperone and immunophilin-like proteins (e.g. HSP90, XAP2/ARA9/AIP, p23), protein kinases and phosphatases (e.g. tyrosine kinases, casein kinase 2, protein kinase C), and coactivators (e.g. SRC-1, RIP 140, CBP/p300). Here we summarize the types of molecular cross talk that have been identified between AhR and cell signaling pathways.
机译：芳基烃（Ah）受体（AhR）是基本螺旋-环-螺旋PER-ARNT-SIM（PAS）转录因子家族的成员。与PAS蛋白是生物传感器的观点一致，AhR与Ah毒物的结合会诱导或抑制多种基因的转录，并导致一系列毒反应。但是，AhR在发育和体内稳态中的内源性作用是由以下因素支持的：（1）低亲和力，内源性配体的发现; （2）研究证明受体在肝脏和血管系统发育中的作用，这些研究是使用缺乏AhR表达的小鼠建立的; （3）在与细胞生长和分化有关的基因的启动子区域中存在功能性二恶英响应元件。大量最新文献已将AhR牵涉到多种信号转导途径中。众所周知，AhR与由雌激素受体和其他激素受体，缺氧，核因子κB和成视网膜细胞瘤蛋白介导的信号通路相互作用。此外，AhR复合物可能通过与各种其他调节和信号蛋白相互作用而影响细胞信号传导，这些蛋白包括PAS异二聚体伴侣（ARNT），分子伴侣和亲免蛋白样蛋白（例如HSP90，XAP2 / ARA9 / AIP，p23），蛋白激酶和磷酸酶（例如酪氨酸激酶，酪蛋白激酶2，蛋白激酶C）和共激活因子（例如SRC-1，RIP 140，CBP / p300）。在这里，我们总结了在AhR和细胞信号通路之间已确定的分子串扰类型。

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